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Answer the following questions:
(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?
(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)
(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.
(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?
Describe about the term - inorganic phosphorus The large quantity of carbon dioxide evolved during organic matter decomposition is thought to be important to the release of ce
The functional organization of the human brain—for instance that the temporal lobe processes auditory and occipital cortex visual information—is largely not hard-wired, unlike in s
The difference between hard and soft water Collect some hard water from a stream(or make some as defined in the next experiment). Also secure some soft water like as rain wate
What are famous life scientist and what did they discover?
Transport: River Valley civilisations were characterised by settlements along the rivers and growth of cities which needed, among.other things, stones and wood from distant
Diabetes : A diabetic patient may lapse into diabetic coma or unconsciousness, but usually the affected person is aware of the symptoms before this occurs. You can assist at any s
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Why is there more exchangeable calcium than potassium on clay/humus colloid? Calcium is usually abundant except in acid soils which occur in humid area due to excessive leaching.
what happens if water runs out
The effect of varying the pH of the yeast solution on the functioning of an enzyme catalase
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