Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Answer the following questions:
(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?
(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)
(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.
(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?
Soil particle distribution The grouping of soil particle distribution into different groups has been done, though arbitrarily, each group represents a range. The limit does no
Endoenzyme An enzyme which is not secreted or exported out of the cell, but is kept and used by the cell which made it.
what are the problems
From the start of this course, we have emphasized the importance of research in shaping our understanding of human behavior and mental process. Several major studies and social psy
Poisons : It is essential that all dangerous substances, such as cyanides, are always kept under strict control. Steps to ensure such control are as follows: i) All substances
Define the visual area of the Cerebrum The visual area lies behind the parieto-occipital sulcus and includes greater part of occipital lobes. Optic nerve passes from eyes to th
Define Volume of Urine - General Examination of Urine Volume: Measurement of the volume of each urine specimen passed is necessary for the conditions in which the fluid balance
Code of Practice in a Laboratory The following is a set of rules you should follow while working in a laboratory: 1. Always wear the required protective clothing. 2. Make
ht are the examples oof a solution and its characteristics?
Discovery of Microbes The discovery of microbes and the fact that they cause infectious diseases is one of the greatadvances in science, which has helped us in understanding
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +91-977-207-8620
Phone: +91-977-207-8620
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd