Physiology-based pharmaco-kinetic (pbpk) models, Science

Assignment Help:

Answer the following questions:

(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?

(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)

(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.

(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?

 


Related Discussions:- Physiology-based pharmaco-kinetic (pbpk) models

Explain functions of gastric juice - digestive function, Explain Functions ...

Explain Functions of Gastric Juice - Digestive function As the gastric juice contains water, it further liquefies the food swallowed. The hydrochloric acid acidifies the stomac

Transformation of medieval economy, The Transformation of Medieval Economy:...

The Transformation of Medieval Economy: The new techniques led to greater production in  agriculture and, therefore, a surplus from the needs of  people. Increased productivi

Define the functions of cerebrospinal fluid, Define the Functions of Cerebr...

Define the Functions of Cerebrospinal Fluid The CSF has many functions. These include the following: 1) It provides the optimum condition for a meaningful signal/stimulus. T

Lifting things with compressed air, Lifting things with compressed air ...

Lifting things with compressed air Remove the bladder from a soccer ball or basket ball and place it on a table. Pile some books on the bladder and then blow into it.

Experiment of the buoyancy of water, Another way to observe the buoyancy of...

Another way to observe the buoyancy of water Push a large cork to the bottom of a pail of water. Notice the quantity of force you have to apply to hold the cork at the bottom.

Role of communication in the economic development, Role of Communication in...

Role of Communication in the Economic Development: This is as much as one-sixth of the world's population. In the year 1981,446 million Indians were illiterate, i.e., they co

Remote sensing, application of remote sensing in land slides and flood cont...

application of remote sensing in land slides and flood control

Procedure identification of compressed gases , PROCEDURE Locate the gas...

PROCEDURE Locate the gas cylinders available in the lab. Note the colour of the cylinder (to a maximum of two and exclude the LPG) and bands on it (if any) and record them i

Iodine value, taken two oil samples A&B ,1st reaction A iodine value will b...

taken two oil samples A&B ,1st reaction A iodine value will be high and reichert meissl value will be low,and then 2nd reaction B iodine value low but reichert meissl value is high

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd