Physiology-based pharmaco-kinetic (pbpk) models, Science

Assignment Help:

Answer the following questions:

(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?

(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)

(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.

(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?

 


Related Discussions:- Physiology-based pharmaco-kinetic (pbpk) models

List the important rice products, Q. List the important rice products? ...

Q. List the important rice products? The important rice products are flaked rice, expanded rice, popped rice, instant rice, rice flour, rice starch etc.

Define the pre motor areas of the cerebrum, Define the Pre Motor Areas of t...

Define the Pre Motor Areas of the Cerebrum The pre motor areas too lie in the frontal lobe immediately anterior to the motor area as highlighted in the Figure. The cells are th

How to prepare hydrogen, How to prepare hydrogen Hydrogen can be prepar...

How to prepare hydrogen Hydrogen can be prepared from a dilute acid, like as hydrochloric or sulphuric, when it is chemically reacted with a metal like as zinc. The acid may be

What are the important processed pulse products, Q. What are the important ...

Q. What are the important processed pulse products? Puffed chickpea and pea, besan, papads, pulse-based weaning foods, quick cooking dhals, and canned dry peas are the importa

DTA., Identification of curves

Identification of curves

Prevention of disease, Prevention of disease: Now that we know that inf...

Prevention of disease: Now that we know that infectious diseases are caused by microbes,  it should be possible to prevent diseases by controlling their transmission and proper

Activity to polluting this water source, Q. Do you know of any activity whi...

Q. Do you know of any activity which may be polluting this water source? Answer: The discharge of waste water from homes, industries, hospitals, etc. into the river pollutes thi

Rockets or launch vehicles, Rockets or Launch Vehicles: Every flight in...

Rockets or Launch Vehicles: Every flight into space begins with a rocket launching. The rocket can lift a satellite or spaceship  carrying human beings and equipment into space

Explain precipitation - antigen-antibody interaction, Explain Precipitation...

Explain Precipitation - Antigen-Antibody Interaction If Ag-Ab are present in an appropriate ratio, they form a precipitate in blood. Turbidity is developed, this can be measure

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd