Physiology-based pharmaco-kinetic (pbpk) models, Science

Assignment Help:

Answer the following questions:

(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?

(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)

(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.

(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?

 


Related Discussions:- Physiology-based pharmaco-kinetic (pbpk) models

Air, why we cannot see air

why we cannot see air

FST-01, #question: Describe the factors which decide the broad area of Scie...

#question: Describe the factors which decide the broad area of Scientific activity ?

Radiation, Radiation: High doses of radiation are very harmful for huma...

Radiation: High doses of radiation are very harmful for human health. Do you know about the disaster ceated by  the first atomic bombs which were exploded on two cities of Japa

Diastrophism, what are all about diastrophism ?

what are all about diastrophism ?

State about the active soil formers, Active Factors or Active Soil Formers ...

Active Factors or Active Soil Formers        It has been recognized for many years that climate  is one of the major state factors controlling soil formation. Soil climate regi

Use of natural resources, Use of natural resources: you studied about v...

Use of natural resources: you studied about various natural resources such as land, water, soil, minerals etc. You know that these resources are limited and precious. Therefore

#titlko, Ask question #Minimum 100 words accept231

Ask question #Minimum 100 words accept231

SZXDASDas, AskDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD question #MinaDASDDimum 100 ...

AskDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD question #MinaDASDDimum 100 words accepted#

Reflexes, Reflexes: It is of  interest  to know,  that all sensory in...

Reflexes: It is of  interest  to know,  that all sensory information does not have to go to the  -  brain before we can react to a stimulus. Our responses to certain stimuli

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd