Physiology-based pharmaco-kinetic (pbpk) models, Science

Assignment Help:

Answer the following questions:

(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?

(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)

(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.

(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?

 


Related Discussions:- Physiology-based pharmaco-kinetic (pbpk) models

How soil textural classes categorised, How soil textural classes categorise...

How soil textural classes categorised and what are is their significance? The soil textural classes are based on the percentage of the separate(s) which contributes maximum to

Photosynthesis, what is an easy way to learn everything about photosynthesi...

what is an easy way to learn everything about photosynthesis?

Applications of optical fibres, Applications of Optical Fibres: Fibre...

Applications of Optical Fibres: Fibre optics finds many applications in areas like medicine and communications which we will briefly describe. We will also discuss  its advht

Powerpoint presentation on pulmonary embolism, Collaborative Learning Commu...

Collaborative Learning Community: a) Literature Review Presentation i) In this assignment, the instructor will place the students into groups. You will be required to work to

Levels, what would i need to do to achieve a 7C in science , KS3??

what would i need to do to achieve a 7C in science , KS3??

Gears, What is the Effect of the Number of Teeth with regards to Rotation?

What is the Effect of the Number of Teeth with regards to Rotation?

Emergence of science, Emergence of Science: We gave you a glimpse of ...

Emergence of Science: We gave you a glimpse of  the social structure in  India during the Iron Age. With the emergence of ordered urban societies, the stage was set for a tre

Explain emphysema - histotoxic hypoxia, Explain Emphysema - Histotoxic Hypo...

Explain Emphysema - Histotoxic Hypoxia Emphysema is a chronic respiratory disease where there is an over- inflation of the air sacs (alveoli) in the lungs, causing a decrease i

What is topography, What is Topography The location of a soil on a land...

What is Topography The location of a soil on a landscape i.e., topography or relief of the land is an important passive factor in soil formation as it can affect the impact of

Describe the various theories for the cause of disease, Question 1 Define ...

Question 1 Define Epidemiology and describe in detail about Disease frequency, Disease distribution and Disease determinants Question 2 Write a short note on mortality data a

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd