Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Answer the following questions:
(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?
(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)
(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.
(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?
Explain the History and Milestones of the Concept of Blood In this section, we will discuss about the historical development of the concept of blood and blood cells. This discu
why don''t we have a crtical point on the solid liquid equilibrium line as we have on the liquid-vapour line...
economic importance
How do minerals become rocks and rocks become soil? Ans) Minerals become rocks by pressure and temperature, often deep inside the earth's core, or easily through pressure for i
whose photosynthesis
A simple mercury barometer Seal single end of a glass tube about 80 cm in length by rotating it in a gas flame. The tube should be held as almost vertical as possible. Join a s
characteristics
To feel the 'spring' of air Secure a bicycle pump and place your thumb over the finish of the outlet tube. Next push the piston in forcibly and rapidly let go of it. What happe
Classification of Fires As explained also. We can say that the four main sources of fire risk in the science laboratory are: i) flammable substances, ii) compressed and
Sinking bodies Fill the overflow can with water to the level of the spout. Select a stone that will go inside the overflow can. Attach a string to the stone and weigh it with a
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +91-977-207-8620
Phone: +91-977-207-8620
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd