Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Answer the following questions:
(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?
(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)
(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.
(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?
Describe about the Moles Molehills, frequently observed in some fields are composed of subsoil deposited by moles. They need a good reserve of calcium in soil.
Define the Sources of sound and their level of loudness Let us now have a look at Table, where the various sources of sound, their level of loudness and its comparison to the f
Digital X-Ray, Inc., has introduced a new line of equipment that may revolutionize the medical profession. Because of the new technology involved, potential users of the equipment
Define age related changes in Cardiovascular system There is a decrease in elasticity of the aorta and other large arteries as age increases. Thickness of blood vessels increas
Explain Neutral fats Neutral fats are esters of fatty acids with glycerol and found abundantly in nature. These are insoluble in water but readily soluble in ether,
A simple mercury barometer Seal single end of a glass tube about 80 cm in length by rotating it in a gas flame. The tube should be held as almost vertical as possible. Join a s
Scientific approach to problem solving: The scientific method and the features of scientific knowledge described above are in no way restricted to the domain of scientists alo
Explain Collecting Duct or Tubules - Structures of a Nephron Collecting Duct/Tubules: A long straight portion after the distal tubule is the open end of the nephron. It extends
Explain Monocytes - Types of White Blood Cells They are motile and occasionally show phagocytic activity. They form only 5% of leukocytes, capable of providing more phagocytic
Mr. X is a 24-year-old Caucasian male. He denied suicidal and homicidal ideation, and was not actively psychotic. He was well-groomed, clean-shaven, and dressed casually in jeans a
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +91-977-207-8620
Phone: +91-977-207-8620
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd