Physiology-based pharmaco-kinetic (pbpk) models, Science

Assignment Help:

Answer the following questions:

(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?

(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)

(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.

(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?

 


Related Discussions:- Physiology-based pharmaco-kinetic (pbpk) models

Water cyclw, why the sun important for the water cycle

why the sun important for the water cycle

To learn the use of a carbon dioxide fire extinguisher, TO LEARN THE USE OF...

TO LEARN THE USE OF A CARBON DIOXIDE FIRE EXTINGUISHER : All chemical laboratories should be provided with carbon dioxide and or dry chemical fire extinguishers. Carbon dioxide fi

Explain the small intestine, Explain the Small Intestine The small inte...

Explain the Small Intestine The small intestine is continuous with the stomach at the pyloric sphincter and leads into the large intestine at the ileocdic valve.  It is about 2

Describe nabh accreditation, Question 1 Discuss the history of quality in ...

Question 1 Discuss the history of quality in healthcare services Question 2 Explain the dimensions of quality in healthcare Question 3 Describe NABH Accreditation

Explain the property of water, Explain the property of Water Water has ...

Explain the property of Water Water has a significant property called surface tension that markedly influences its behaviour in soils and may be measured by level of water rise

Turing Machine, How do i make the simulator write a program for a Turing Ma...

How do i make the simulator write a program for a Turing Machine to detect sequences of 1s and 0s that ends in “0”?

Explain agglutination - antigen-antibody interaction, Explain Agglutination...

Explain Agglutination - Detection of Antigen-Antibody Interaction Agglutination - If Ag is present on the surface of cells, or can be made to coat these surfaces of cells, thes

Explain Metabolism, Metabolism   All  of  the  organized  chemical  reactio...

Metabolism   All  of  the  organized  chemical  reactions  in  a  cell  which  are under the control of enzymes.

Define the pons varolli, Define the Pons Varolli Look at Figure Situate...

Define the Pons Varolli Look at Figure Situated in front of the cerebellum below the midbrain and above the medulla oblongata, is the pons. It is involved in motor control and

Explain riboflavin (vitamin b2), Riboflavin (vitamin B2) Riboflavin was...

Riboflavin (vitamin B2) Riboflavin was isolated in  a crystalline form from milk by Kuhn  and co-workers in 1933.  Because of this,  the  early  name  of  the  vitamin  was  la

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd