Physiology-based pharmaco-kinetic (pbpk) models, Science

Assignment Help:

Answer the following questions:

(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?

(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)

(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.

(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?

 


Related Discussions:- Physiology-based pharmaco-kinetic (pbpk) models

Explain the autonomic nervous system, Explain the Autonomic Nervous System ...

Explain the Autonomic Nervous System (ANS) The autonomic or involuntary part of nervous system controls the functions of the body carried out automatically i.e. initiated in th

Segnificant figure, give the importants segnificant figure in measure quant...

give the importants segnificant figure in measure quantities

Is psychology a science, QUESTION a) Is Psychology a science? Explain w...

QUESTION a) Is Psychology a science? Explain with an appropriate definition b) How does the knowledge of psychology help you deal with people in your everyday life? c) Desc

Define age related changes in endocrine system, Define age related changes ...

Define age related changes in Endocrine system There is a decrease In blood concentration of the hormone / binding protein transport. Sensitive hormone receptors diminish. Age-

Lowing soap bubbles with hydrogen, Lowing soap bubbles with hydrogen Mi...

Lowing soap bubbles with hydrogen Mix up a strong soap solution that will make good soap bubbles. Place a small funnel tube or a clay pipe on the delivery tube. When you have a

Environmental science, The debris resulting from mountaintop removal mining...

The debris resulting from mountaintop removal mining is Answer A. dumped into valleys and streams below B. ground and combined with cement to make concrete C. resold as soil

How temperature influences the process of soil formation, How temperature i...

How temperature influences the process of soil formation Temperature is another climatic agent which influences the process of soil formation.  It affects the P/E ratio.  If th

Explain hypercapnia and hypocapnia - histotoxic hypoxia, Explain Hypercapni...

Explain Hypercapnia and Hypocapnia - Histotoxic Hypoxia Hypercapnia: It is the retention of carbon dioxide in the body. There is a depression of the central nervous system.

Boobs, why are boobs fluffy

why are boobs fluffy

Arthropoda, structure and function of respiratory organs in arthropoda with...

structure and function of respiratory organs in arthropoda with diagram

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd