Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Answer the following questions:
(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?
(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)
(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.
(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?
Moisture comes from home plants Place a cellophane bag over a leaf of some house plant or garden plant and close the end about the stem with a rubber band. Make an observation
Explain the Somatosensory System The somatosensory system consists of: 12 pairs of cranial nerves, and 31 pairs of spinal nerves All our conscious awaren
how much precipitation is there in the tundra
life span of a roundworm
Explain Gut secretions - External Defence Mechanism From the saliva and respiratory tract, bacteria reach the gut, here they are killed by the hydrochloric acid and proteolytic
#ghhytiquestion..
Which are clouds formed at the highest altitude: cirrocumulus
porogamic fertilization
Define Hypovolemia or Reduction in Blood Volume Hypovolemia leads to a decrease in cardiac output, which causes a fall in the systemic blood pressure. Hypovolemia may be produc
#question.I AM TRAYING TO DO A SCIENCE PROJECT FOR 7TH GRADE BUT I DONT KNOW WHAT SHOULD I DO ?
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +91-977-207-8620
Phone: +91-977-207-8620
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd