Physiology-based pharmaco-kinetic (pbpk) models, Science

Assignment Help:

Answer the following questions:

(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?

(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)

(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.

(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?

 


Related Discussions:- Physiology-based pharmaco-kinetic (pbpk) models

Substantial amounts of corundum and magnetite, What common type of paper ha...

What common type of paper having substantial amounts of corundum and magnetite? Sand Paper

Explain the role of secretin, Explain the Role of secretin Secretin is ...

Explain the Role of secretin Secretin is a polypeptide containing 27 amino acids. It is present in the mucosa of the upper small intestine in an inactive form prosecretin. When

Explain loam soil, What is loam soil? This is a type of soil, which is ...

What is loam soil? This is a type of soil, which is halfway among clay and sandy soils.

Ozone gas, how does it get into the earth?

how does it get into the earth?

Explain the structure of tongue, Explain the Structure of Tongue The to...

Explain the Structure of Tongue The tongue is a muscular organ. It is covered with a mucous membrane. The tongue is attached by its base to the hyoid bone and by a fold of its

Preparation of oil from oilseeds, Q. List the main steps involved in the pr...

Q. List the main steps involved in the preparation of oil from oilseeds? The main steps involved in the preparation of oil from oilseeds are: preparation of the raw material,

What is pedology, What is Pedology Pedology is concerned with the study...

What is Pedology Pedology is concerned with the study of the composition, distribution and formation of soils as it occurs in nature.  On the other hand edaphology is the study

Measuring atmospheric pressure with a bicycle pump, Measuring atmospheric p...

Measuring atmospheric pressure with a bicycle pump A bicycle pump with the washer reversed as represents can be used to calculate atmospheric pres- sure. The piston can be made

Media and distance education, Media and Distance Education: The role of...

Media and Distance Education: The role of media in distance education needs a specific mention. It is impIied that teaching is done  from a dbtance. It is also understood that

Science in the post-renaissance period (1540- 1760) , Science in the post-...

Science in the post-renaissance period  (1540- 1760): We have seen above that  improved techniques as well as growing trade had  led to great voyages to many lands. These were

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd