Physiology-based pharmaco-kinetic (pbpk) models, Science

Assignment Help:

Answer the following questions:

(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?

(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)

(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.

(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?

 


Related Discussions:- Physiology-based pharmaco-kinetic (pbpk) models

Endomitosis, why and where endomitosis happen?

why and where endomitosis happen?

Explain sinus tachycardia - electrocardiogram, Explain Sinus Tachycardia - ...

Explain Sinus Tachycardia - Electrocardiogram When the only abnormality is that the heart rate at rest is more than 100 per minute, the condition is known as sinus tachycardia.

Explain in detail about the viruses, Explain in detail about the Viruses ...

Explain in detail about the Viruses Viruses are the ultramicroscopic parasites which always require a living h ost for their multiplication. Since they are much smaller than ba

Regulations concerning safety and health, REGULATIONS CONCERNING SAFETY AND...

REGULATIONS CONCERNING SAFETY AND HEALTH OF WORKERS IN INDUSTRIAL LABORATORIES The workers in industry engaged in using or producing chemicals, coal, high temperature, intense

Explain cis-isomer, Cis-isomer : Both hydrogen atoms located on the same...

Cis-isomer : Both hydrogen atoms located on the same side of the double bond.

Spontaneous generation, Spontaneous Generation: If  we look around at o...

Spontaneous Generation: If  we look around at our everyday environment, we observe that straw, soil, mud, dirt, indeed any sort of refuse or rotting matter  is infested with  a

What is the meaning of manures, What is the meaning of Manures The way ...

What is the meaning of Manures The way fertilizers affect soil productivity, organic matters in soil are also associated with soil fertility.  This is because a soil rich in or

The fire triangle, The Fire Triangle Generally, a fire needs three thin...

The Fire Triangle Generally, a fire needs three things to burn: Fuel - something to bum, e.g.oi1. Oxygen - to maintain combustion. Ignition - something to start

How different pressures of air force water from a container, How different ...

How different pressures of air force water from a container Fit a test tube with a two-hole stopper. By one hole place a length of glass tube which extends into the test tube a

Diabetes administer first aid , Diabetes : A diabetic patient may lapse in...

Diabetes : A diabetic patient may lapse into diabetic coma or unconsciousness, but usually the affected person is aware of the symptoms before this occurs. You can assist at any s

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd