Phases of Karyokinesis:

Karyokinesis can further be divided into prophase, metaphase, anaphase and telophase.

1-Prophase: (pro= before)

Chromatin: During Interphase (non- dividing) of the cell cycle the chromosomes are not visible even with electron microscope, but using histological stains for DNA, a network of very fine threads can be visualized. This network is called as chromatin.

Appearance of chromosomes: The chromatin material gets condensed by folding and chromosomes appear as thin threads at the beginning of prophase.

Appearance of Sister chromatids: Chromosomes becomes more and more thick ultimately each chromosomes is visible having two sister chromatids, attached at centromere.

Disappearance of Nucleoli: Towards the end of the prophase, nuclear envelope disappears and nuclear material is released in the cytoplasm.

Disappearance of Nucleoli: Nucleoli disappear.

Mitotic Apparatus: Mitotic apparatus is organized.