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Phases of Karyokinesis:
Karyokinesis can further be divided into prophase, metaphase, anaphase and telophase.
1-Prophase: (pro= before)
Chromatin: During Interphase (non- dividing) of the cell cycle the chromosomes are not visible even with electron microscope, but using histological stains for DNA, a network of very fine threads can be visualized. This network is called as chromatin.
Appearance of chromosomes: The chromatin material gets condensed by folding and chromosomes appear as thin threads at the beginning of prophase.
Appearance of Sister chromatids: Chromosomes becomes more and more thick ultimately each chromosomes is visible having two sister chromatids, attached at centromere.
Disappearance of Nucleoli: Towards the end of the prophase, nuclear envelope disappears and nuclear material is released in the cytoplasm.
Disappearance of Nucleoli: Nucleoli disappear.
Mitotic Apparatus: Mitotic apparatus is organized.
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