Pathophysiology of aortic regurgitation, Biology

Assignment Help:

Q. Pathophysiology of aortic regurgitation?

Left ventricle responds to chronic aortic regurgitation by chamber dilatation and an increase in its compliance so that end diastolic pressure does not increase. This is accompanied by rearrangement of muscle fibers and addition of new sarcomeres leading to eccentric hypertrophy.

As the chamber dilates-with preserved systolic function - stroke volume increases compensating the regurgitant volume. However, dilated chamber increases wall stress and afterload and to compensate for the increased afterload concentric hypertrophy ensues. Thus, chronic aortic regurgitation represents combined volume and pressure overload. During this compensatory phase involving preload reserve and concentric and eccentric hypertrophy, patient remains asymptomatic with preserved left ventricular systolic function but with dilated left ventricle. This can go on for many years. Patient becomes symptomatic as the preload reserve gets exhausted and end diastolic pressure increases. Further increase in afterload leads to afterload mismatch and left ventricular systolic function declines. The changes occur very insidiously and patient may remain asymptomative till severe LV dysfunction sets in. As the chamber enlargement proceeds and geometry alters depressed myocardial function occurs and predominates over afterload mismatch.

Though both mitral and aortic regurgitation cause volume overload to left ventricle-aortic regurgitation has additional pressure overload as the increased stroke volume has to be ejected into high impedance aorta. This is also borne out by the increased left ventricular end systolic wall stress. In mitral regurgitation, the initial compensatory mechanism is increased ejection fraction with little ventricular dilatation but in aortic regurgitation it is ventricular dilatation with preserved ejection fraction.

In aortic regurgitation, coronary perfusion is impaired due to decreased aortic diastolic pressure and increased oxygen demands. This in severe cases leads to sub endocardial ischaemia.


Related Discussions:- Pathophysiology of aortic regurgitation

What are gonads, What are gonads? What are the male and the female gonads i...

What are gonads? What are the male and the female gonads in humans? Gonads are the organs that make gametes. They have the germ cells that undergo division and generate gametes

Verify that the transforming agent in a bacteriophage, Which of the followi...

Which of the following experimental steps permitted Hershey and Chase to verify that the transforming agent in a bacteriophage is DNA as well? A. Phage particles were mixed wit

Deficiency diseases-post-parturient haemoglobinuria (pph), Post-parturient ...

Post-parturient haemoglobinuria (pph) in cattle and buffaloes The post-parturient haemoglobinuria (PPH) is an acute disease of high yielding buffaloes and cows. The disease oc

Respiratory system in fishes, The fishes belong to class Pisces under verte...

The fishes belong to class Pisces under vertebrates. 2. In fishes, the respiratory system consists of mouth, pharynx, internal branchial apertures, branchial pouches and external b

Define the effect of breastfeeding on mother, Normal 0 false ...

Normal 0 false false false EN-IN X-NONE X-NONE

What are vectors of parasites, Q. What are vectors of parasites? The Ve...

Q. What are vectors of parasites? The Vectors of a parasite are organisms can transport the parasite during stages of its life cycle mediating the infection of other hosts. For

Gene targeting, Gene targeting: There is always a debate on gene integrat...

Gene targeting: There is always a debate on gene integration in to the host animal. It is random gene integration Vs gene targeting. Perhaps most significantly, pro-nuclear in

Define beneficial effects of functional foods, Define beneficial effects of...

Define beneficial effects of functional foods? Several beneficial effects of functional foods have been reported, which include effects such as antioxidant, anticarcinogenic, b

Explain about the micronutrient deficiencies, Explain about the Micronutrie...

Explain about the Micronutrient Deficiencies? Micronutrient deficiencies are more common during calamities. Can you guess, why? This is due to the lack of diversified food item

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd