Oxidation of enzymes action, Biology

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Oxidation

Some enzymes which have the sulfhydryl (-SH)  group in  the catalytic site are very sensitive to oxidation. Due  to oxidation of  the  -SH  group  by  aerial  oxygen  or oxidizing agents,  a  disulfide  linkage  (-S-S-)  forms with  the  subsequent loss of enzyme activity. The enzyme activity can be restored by  the reduction of the enzyme by  some reducing agent such as cysteine or glutathione.

 


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