Original hodgkin-huxley model, Mechanical Engineering

Assignment Help:

1. Plot the functions x1 and x as functions of voltage

2. Assume that you hold the membrane potential V at -120 mV until the system reaches equilibrium (i.e. until dx=dt = 0, where x = (V;m; h; n; a; b;M;H)T ) and that at time t = 0 you suddenly change and hold the value of the membrane potential at a value Vo. Plot the currents IL, INa, IK, IA, ICaT as well as the total current as functions of time for a number of di erent values Vo of you choice in the range -75 to +40 mV.

3. Write an algorithm for numerically approximating the solution to the above model.

4. Using the algorithm you developed in Question 2, illustrate the presence of post-inhibitory rebound (PIR) in the above model.

5. Using the algorithm you developed in Question 2 and assuming that ICaT is completely blocked (i.e. GCaT = 0), construct the gain function of the above model.

6. How does the gain function you constructed in Question 5 di er from the gain function of the original Hodgkin-Huxley model?


Related Discussions:- Original hodgkin-huxley model

Wrought aluminium alloys, Wrought Aluminium Alloys Extrusion ingots an...

Wrought Aluminium Alloys Extrusion ingots and sheets are cast through semi-continuous direct chill method. The sheet ingots are scalped in which about 12 millimeter of ingot s

Fundamental geometric transformation, Fundamental geometric transformation:...

Fundamental geometric transformation: The fundamental geometric transformation is Rotation, Translations and Scaling. Other transformations involve reflection and shearing. Tr

Bending stresses, Determine: Reaction forces at the supports The shear an...

Determine: Reaction forces at the supports The shear and moment diagrams The location and value of the maximum shear and moment The cross section is an angle section as given in

Define the nature of force in a member of truss, Define the nature of force...

Define the nature of force in a member of truss: How can you define the nature of force in a member of truss? Sol.: We know that whenever force is applied on a cross se

Determine the reactions at beam, Determine the reactions at bea: A can...

Determine the reactions at bea: A cantilever AB, 1.8 m long is fixed at A and carries uniformly distributed load of 20 kN/m over its entire length and a point load of 30 kN at

Kinematics-dynamics-kinematic link, Kinematics: This is that branch of Th...

Kinematics: This is that branch of Theory of Machines that deals with the relative motion among the several machine parts; without referring forces or torques that cause motion.

Proell governor., how to solve numerical of proell governor

how to solve numerical of proell governor

Represent moment graphically - mechanics, Represent moment Graphically: ...

Represent moment Graphically: How you represent moment Graphically? Sol.: Consider force F which is represented in magnitude and direction, by   line AB . L

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd