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1. Plot the functions x1 and x as functions of voltage
2. Assume that you hold the membrane potential V at -120 mV until the system reaches equilibrium (i.e. until dx=dt = 0, where x = (V;m; h; n; a; b;M;H)T ) and that at time t = 0 you suddenly change and hold the value of the membrane potential at a value Vo. Plot the currents IL, INa, IK, IA, ICaT as well as the total current as functions of time for a number of di erent values Vo of you choice in the range -75 to +40 mV.
3. Write an algorithm for numerically approximating the solution to the above model.
4. Using the algorithm you developed in Question 2, illustrate the presence of post-inhibitory rebound (PIR) in the above model.
5. Using the algorithm you developed in Question 2 and assuming that ICaT is completely blocked (i.e. GCaT = 0), construct the gain function of the above model.
6. How does the gain function you constructed in Question 5 di er from the gain function of the original Hodgkin-Huxley model?
Using Mohr's Circle Method determine the stresses acting on the plan as shown in figure. Also write the procedure.
An inside cylinder locomotive has its cylinder centre lines 0.70m apart and has a stroke of 0.60m. Rotating mass per cylinder = 150kg Distance between wheel Centre lines = 1.
Fatigue crack propagation: If it is assumed that no plastic deformation occurs around crack tip and law of fatigue crack propagation for place of above Example is da/dN = 10
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