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1. Plot the functions x1 and x as functions of voltage
2. Assume that you hold the membrane potential V at -120 mV until the system reaches equilibrium (i.e. until dx=dt = 0, where x = (V;m; h; n; a; b;M;H)T ) and that at time t = 0 you suddenly change and hold the value of the membrane potential at a value Vo. Plot the currents IL, INa, IK, IA, ICaT as well as the total current as functions of time for a number of di erent values Vo of you choice in the range -75 to +40 mV.
3. Write an algorithm for numerically approximating the solution to the above model.
4. Using the algorithm you developed in Question 2, illustrate the presence of post-inhibitory rebound (PIR) in the above model.
5. Using the algorithm you developed in Question 2 and assuming that ICaT is completely blocked (i.e. GCaT = 0), construct the gain function of the above model.
6. How does the gain function you constructed in Question 5 di er from the gain function of the original Hodgkin-Huxley model?
Design a concrete pedestal for a steel column carrying a dead load of 600 kN and an imposed load of 600 kN. Assume the base plate is 350 mm x 350 mm M20 grade concrete and F e , 41
Connecte d Rod: It is attached to piston at its small end by means of gudgeon pin. The big end bearing is connected to crank pin. It is made up of forged steel.
Loose piece pattern This type of pattern is also used when the contour of the part is such that withdrawing the pattern from the mould is not possible. Hence during moulding th
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form tool design
how bike''s hydraulic shock absorbers work?
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Synthesize a mechanism to prepare a function y = log x for 1≤ x ≤ 2 where three precision points are needed, for these precision points Calculate φ 2 , φ 3 and ψ 2 , ψ 3 ; if Δφ
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