Original hodgkin-huxley model, Mechanical Engineering

Assignment Help:

1. Plot the functions x1 and x as functions of voltage

2. Assume that you hold the membrane potential V at -120 mV until the system reaches equilibrium (i.e. until dx=dt = 0, where x = (V;m; h; n; a; b;M;H)T ) and that at time t = 0 you suddenly change and hold the value of the membrane potential at a value Vo. Plot the currents IL, INa, IK, IA, ICaT as well as the total current as functions of time for a number of di erent values Vo of you choice in the range -75 to +40 mV.

3. Write an algorithm for numerically approximating the solution to the above model.

4. Using the algorithm you developed in Question 2, illustrate the presence of post-inhibitory rebound (PIR) in the above model.

5. Using the algorithm you developed in Question 2 and assuming that ICaT is completely blocked (i.e. GCaT = 0), construct the gain function of the above model.

6. How does the gain function you constructed in Question 5 di er from the gain function of the original Hodgkin-Huxley model?


Related Discussions:- Original hodgkin-huxley model

Determine the thermal efficiency of cupola, With the help of neat diagrams ...

With the help of neat diagrams explain various parts of Cupola. Define its operation. How the thermal efficiency of Cupola calculated? What do you mean by Die casting process? G

Final stress analysis, Once vendor drawings are received and piping isometr...

Once vendor drawings are received and piping isometric drawings are prepared, the Mechanical engineer will provide a final stress package to the stress engineer per The stress a

Determine shear plane angle, The following data was obtained from an orthog...

The following data was obtained from an orthogonal cutting test : Rake angle = 20o, Depth of cut = 6 mm Feed rate = 025 mm/rev Chip length before cutting = 29.4 mm Chip

Calculate the magnitude of maximum bending moment, Calculate the magnitude ...

Calculate the magnitude of maximum bending moment: The shear force diagram for the overhanging beam is illustrated in Figure. Draw the loading diagram & bending moment diagram

Corrosion resistance of the austenitic stainless steels, The corrosion resi...

The corrosion resistance of the austenitic stainless steels (within the concentration and temperature conditions described above) relies on the formation and stability of a passive

Concept of centrifugal tension, Concept of centrifugal tension: Expl...

Concept of centrifugal tension: Explain concept of centrifugal tension in any belt drive. What is main consideration for taking maximum tension? Sol: T he belt continuo

Bucket conveyors, Bucket conveyors are used to moves the granular powde...

Bucket conveyors are used to moves the granular powdered or liquid materials. The buckets may be mounted on a chain or a belt. The movement may be vertical or flat. The ver

Cyclone dip tube length calculation., how can we calcute the length of dip ...

how can we calcute the length of dip tube and what are its effects on cyclone efficiency if we change its length

Calculate tensions in chain and chord - mechanics, Calculate tensions in ch...

Calculate tensions in chain and chord - Mechanics: A lamp of mass 1Kg is hung from the ceiling by a chain and is pulled aside by horizontal chord until the chain makes an ang

Composite Materials, One can increase the toughness of a ceramic material b...

One can increase the toughness of a ceramic material by introducing fibers to the structure of the ceramic and create a ceramic-matrix composite. However, unlike other fiber-reinfo

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd