Muromonab cd-3 , Biology

Assignment Help:

Muromonab CD-3 (Orthoclone, OKT-3)

A monoclonal antibody against mature T lymphocytes, OKT-3 is primarily used to treat acute rejection episode. IV for 10-14 days. Effect monitorcd by T lymphocytes count and by serum levels of OKT-3.

Adverse effect:

Chills, fever lasting upto one hour. Respiratory symptoms may occur and be life-threatening if the patient is fluid overloaded. Aseptic meningitis, infection with cytomegalo-virus or herpes simplex virus can occur.

Headache and flue-like symptoms may develop.

Most side-effects occur during the first two doses. To reduce some of the side- effects, the patient may be given methylprednisolone, acetaminopen and anti- histamine before OKT-3 is administered. Monitor the patient intensively for the
first two doses, vital every 15 minutes.

Signs and symptoms of acute rejection in heart transpIants patients Sjmptoms: fatigue, lethargy, dyspnea, decreased tolerance for exercise.

Signs:

fluid retention, peripheral edcma, jugular venous distention, crackles, pericardial friction rub, ECG changes-dysrhythmias and decreased voltage, decreased cardiac output, hypotension, cardiac enlargcrnent.

Identify the signs and sylnptoms and assist with treatment to improve the condition.

Endocardial biopsy is the major diagnostic test used to assess rejection. The patient showing signs of rejection may be treated with increasing doses of immunosuppressive agents. For prevention of infection specially pulmonary infection-hand washing, use of aseptic technique for all invasive procedures. Provide care that protects surface barriers form organism-mouth care after every meal, upon rising and at bed time, cleaning the skin folds by daily washing, lubricating and keeping moisture free.

Deep breathing exercises two hourly. Adequate nutrition, fluid intake. Avoid contact with the patient if care giver is with active infection.


Related Discussions:- Muromonab cd-3

Enumerate the term - clinical neuroscience, Enumerate the term - Clinical n...

Enumerate the term - Clinical neuroscience Clinical neuroscience concerns the study of clinical populations both to well understand neuroanatomy and to test psychological theor

Explain mid-diastolic and lafe diastolic pre systolic sound, Explain Mid-di...

Explain Mid-diastolic and Lafe Diastolic (Pre Systolic) Sounds ? Mid-diastolic sounds are S3 sounds and late diastolic (pre systolic) sounds are S3 sounds. Pre systolic Pacema

What is the mendels first law, What is the Mendel's first law? The Mend...

What is the Mendel's first law? The Mendel's first law postulates that a characteristic (trait) of an individual is always verified by two factors, one inherited from the fathe

Biochemistry, Water is most dense and thus heavier at 4 degreese celceus. A...

Water is most dense and thus heavier at 4 degreese celceus. At 0 degreese celceus ice forms and can float on liquid water. Assuming that ice were most dense at 0 degreese celceus,

Insulin binding to insulin receptors in the plasma membrane, Insulin bindin...

Insulin binding to insulin receptors in the plasma membrane of a A. liver cell will lead to an increase in the intracellular amounts of cAMP in the liver cell. B. beta-islet

Management and nutritional intervention using mna, Define Management and Nu...

Define Management and Nutritional Intervention using MNA - Undernutrition? A. For those categorized as well-nourished They need only be reminded of the importance

Oxidative phosphorylation occurs in the inner membrane, In  eukaryotes,  th...

In  eukaryotes,  the electron  transport  and oxidative phosphorylation occurs in the inner membrane of mitochondria.  These processes re-oxidize the FADH 2 and NADH   which comes

Explain about post-operative pain, Post-operative pain  There is some d...

Post-operative pain  There is some discomfort for about 24-48 hours. Persistent pain for a longer duration, with swelling, may indicate possible infection around the implant an

Bacteria and archea, Based on the scientific name. Streptococcus agalactia...

Based on the scientific name. Streptococcus agalactiae what morphology would you expect these cells to have?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd