Multicausal nature of cancer, Biology

Assignment Help:

Multicausal Nature of Cancer

With several dividing cells in the organism and the various proto-oncogenes and tumor suppressor genes that can be changed to cause cancer. one might expect cancer to be a more common event than it is. Several biologists believe that probably our/body has many initiated cells acquired throughout our life time but the several defense mechanisms of the body destroy them before they can cause cancer. Increasing proof now suggests that any single mutation in a cell is never by itself enough to cause cancer. Just only when a single cell suffers several sequential mutations does it lastly lose its regulation over its cell cycle and a fully fledged cancer results. One of the diseases which explains this concept is colorectal cancer. Primarily, in normal epithelium a suppressor gene on chromosome 5 is inactivated or lost. Next comes hypomethylation of DNA that is followed by mutation of ras proto-oncogene.

The losses of chromosomes 18 and 17 whole the transformation into a cancer cell. Further chromosome losses give the tumor the ability to form metastases. More and more research is being done on what in fact activates or turns on the genes in tumor cells and the role that individual oncogenes play in making the cells cancerous. By comparing DNA sequences of known oncogenes along with genes for cell growth and growth receptors, investigators have begun to identify key genes. For instance, an oncogenes has been found to correspond to the gene that functions as a growth factor in the healing of wounds. The invention of newer oncogenes is leading towards a better understanding of normal cell growth pathways and as well the-role of proto-oncogenes in development processes. The current efforts in prevention and treatment of cancers are characterized via a multidisciplinary approach. Early detection and characterization of the tumor is an important prerequisite for effective treatment. Understanding the cellular and molecular aspects of growth, differentiation and neoplastic change will provide clues to development of effective drugs for treatment. The combined efforts of developmental biologists and medical scientists can eventually lead to alleviation of human suffering from the disease.


Related Discussions:- Multicausal nature of cancer

Berry - development of seed, Berry - Development of Seed In a berry mu...

Berry - Development of Seed In a berry much of the pericarp is fleshy or juicy. In tomato Lycopersicon esculentum even the placenta on which the seeds are borne is fleshy. The

What is the binding between two amino acids, Q. What is the binding between...

Q. What is the binding between two amino acids called? The chemical bond between two amino acids is called a peptide bond.

Detailed explanation of effects of air pollution, On living organism  ...

On living organism           Air pollution causes following effects on living organism: (a)   Effects on humans: 1.      Carbon monoxide reduces the oxygen carrying cap

Cerebral palsy, Cerebral Palsy Cerebral palsy is a non-progressive neu...

Cerebral Palsy Cerebral palsy is a non-progressive neuromuscular disorder characterised by disorder of strength, muscle control, posture or movement due to brain injury, befor

What a cell with a euploid number of chromosomes contains, A cell with a eu...

A cell with a euploid number of chromosomes contains: A.one half of a complete set of chromosomes B.several complete sets of chromosomes C.the correct number of chromosomes D.two c

Define determinants of food security - food access, Define Determinants of ...

Define Determinants of Food Security - Food Access? Food access is linked to its affordability. Food access is ensured when households and all individuals within them have adeq

Explain horizontal full mucoperiosteal flaps, Explain Horizontal Full Mucop...

Explain Horizontal Full Mucoperiosteal Flaps - Endodontic Surgery      a) Also called:  Envelope flap, b) Only a Horizontal incision, without the vertical releasing incision

Contraindications for beta-blockers, Reversible airways obstructive disease...

Reversible airways obstructive disease, advanced heart block, or episodic decompensation.  Vasodilators Agents that dilate arteriolar smooth muscle and lower peripheral vascu

Which term explains to pituitary gland, In studies of human body, which of ...

In studies of human body, which of the subsequent terms can also be used when referring to the pituitary gland? Is it: a) Pancreas b) Hypozthesis (pron: hypo-fi-sis) c) T

Protein synthesis with dna, Protein Synthesis with DNA The central dogm...

Protein Synthesis with DNA The central dogma of modern biochemistry is totally based on the coded information holded within deoxyribonucleic acid (DNA). Double stranded DNA is

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd