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Metaphase chromosomes:
Each metaphase chromosomes is a duplicated structure which consists of two sister chromatids, attached at a point called centromere or primary constriction. The centromere has special area the kinetochore, with specific base arrangement and special proteins where kinetochore fibers of mitotic apparatus attach.
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PKU is a recessive disorder. Suppose two people who were heterozygous for PKU married and had a child. What is the probability that the child will have PKU?
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