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Mendelian randomization is the term applied to the random assortment of alleles at the time of gamete formation, a process which results in the population distributions of genetic variants which are generally independent of the behavioural and environmental factors which typically confound epidemiologically derived associations between the putative risk factors and disease. In some of the circumstances taking the advantage of Mendelian randomization might provide an epidemiological study with properties of a randomized comparison, for instance, a randomized clinical trial. In particular, the use of the Mendelian randomization might allow causal inferences to be drawn from epidemiological studies, typically using the instrumental variable estimator.
what is pdf,mean & variance for multimodal distribution?
An investor with a stock portfolio sued his broker, claiming that a lack of diversification in his portfolio had led to poor performance. The data, shown below, are the rates of re
Law of likelihood : Within framework of the statistical model, a particular set of data supports one statistical hypothesis or assumption better than another if the likelihood of t
Multiple imputation : The Monte Carlo technique in which missing values in the data set are replaced by m> 1 simulated versions, where m is usually small (say 3-10). Each of simula
Johnson''s Job Sequencing for n jobs and 2 machines
Interim analyses : An analysis made before the planned end of a clinical trial, typically with the aim of detecting the treatment differences at the early stage and thus preventing
The values assigned to factors for the individual sample units in a factor analysis. The most common approach is "regression method". When the factors are seen as the random variab
The measure of the degree to which the particular model differs from the saturated model for the data set. Explicitly in terms of the likelihoods of the two models can be defined a
Missing Data - Reasons for screening data In case of any missing data, the researcher needs to conduct tests to ascertain that the pattern of these missing cases is random.
Influence statistics: The range of statistics designed to assess the effect or the in?uence of an observation in determining results of the regression analysis. The general approa
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