Johne''s disease, Biology

Assignment Help:

Johne's disease

It is also known as paratuberculosis characterized by chronic enteritis and progressive weakness in dairy animals.

Etiology: Mycobacterium paratuberculosis, the causative organism for this chronic disease, is an acid fast and comparatively resistant bacillus. The principal mode of spread of disease is through ingestion of contaminated feed or water or through intrauterine route. Morbidity rates are high but mortality is only 1-10% and main losses result from reduced production or weight gain.

Pathogenesis: Organisms localize in the intestinal mucous membrane and adjoining lymph nodes and multiply there.

Clinical signs: In cows, there is reduced milk production, progressive weight loss and submandibular edema. There is diarrhoea and faeces resemble pea soup and are without offensive odour. Feed intake remains normal but water intake is increased. In sheep and goats, faeces are soft but diarrhoea is usually not seen. The animals show progressive weakness and alopecia. In goats depression and dyspnoea are additional signs.

Diagnosis: It is diagnosed by clinical signs and history of persistent diarrhoea and continuous but slow weight loss. It can be confirmed by performing intra-dermal Johnin test. Johnin PPD 0.2 ml is injected by intra-dermal route in the cervical region. In positive cases, skin thickness at injected site increases by 3 mm or more by 48 to 72 h. Faecal or rectal pinch examination also confirms the disease. Serological tests like indirect fluorescent antibody, ELISA and complement fixation tests are also confirmatory. The organisms can be grown from faecal samples. However, none of these tests taking one at time can detect all the cases of paratuberculosis, so 2 or 3 tests are performed for its diagnosis. The advanced clinical cases can be diagnosed easily by clinical symptoms, faecal examination and antibody response of the host while preclinical cases can be detected by lymphocyte transformation, antibody response and faecal examination. Resistant animals can only be diagnosed by lymphocyte transformation test.

Treatment: The treatment is difficult as organisms are mostly resistant to antibiotics and it requires prolonged treatment. There is some recovery, if animals are treated with streptomycin @ 50 mg/kg body weight for 20-30 days. Combination of 500 mg dihydrostreptomycin intramuscularly and 300 mg- each of rifampin and isoniazied given twice daily orally were found effective in goats.

Control: The long incubation period and lack of single diagnostic test makes the disease difficult to control. Eradication of infected animals and carriers and maintenance of strict hygienic conditions are of some value. An animal herd may be declared free of paratuberculosis only when they do not show symptoms up to 3 years, feacal culture of above 2-year-old animals is negative and Johnin testing gives negative results.


Related Discussions:- Johne''s disease

Explain the repair mechanisms of brain, Explain the repair mechanisms of br...

Explain the repair mechanisms of brain Scientists are just beginning to understand how these innate repair mechanisms might be harnessed to treat disease. On leading edge of th

Brain region that triggers the voluntary motor activity, Which is the brain...

Which is the brain region that receives conscious sensory information? Which is the brain region that triggers the voluntary motor activity? In the brain conscious sensory info

Find which of the following is most stable, Hydrogen ( h) has 1 electron; C...

Hydrogen ( h) has 1 electron; Carbon ( c) has 6 electrons, use the octet rule to determine which of the following is most stable. Note: some of these may have double bonds. A. O

Explain the working of conical flasks, Explain the working of Conical Flask...

Explain the working of Conical Flasks? Conical flasks of different volumes can be used for media preparation and also for culturing large amount of microorganisms in liquid med

Explain the neurological and sensory system, Neurological and Sensory Syste...

Neurological and Sensory System There are three neurological systems: sensory, motor and autonomic. Sensory system consists of sensory receptors, sensory nerve fibres. Differen

Describe postpartum cardiomyopathy, Q. Describe Postpartum Cardiomyopathy? ...

Q. Describe Postpartum Cardiomyopathy? It is defined as presentation of LV Systolic dysfunction and heart failure in last trimester of pregnancy or within 6 months of delivery.

How chloroplasts multiply, Q. How chloroplasts multiply? Like mitochond...

Q. How chloroplasts multiply? Like mitochondria chloroplasts have their own the DNA, ribosomes and RNA and they self-replicate through binary division.

What is green fluorescent protein, Q. What is green fluorescent protein (GF...

Q. What is green fluorescent protein (GFP)? Green fluorescent protein is a protein which is found in a luminescent jellyfish (Aquorea victoria) that lives in cold waters of nor

Translation in prokaryotes, Term Translation or protein synthesis, is quite...

Term Translation or protein synthesis, is quite similar in eukaryotes and prokaryotes. We will look at the details of the process in prokaryotes and consider the differences in euk

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd