Inotropic agents, Biology

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All currently available inotropic agents act to increase Ca2+ for activation in both normal and failing myocardium (Hurst). The use of inotropic agents in the treatment of CHF is predicated on the finding that a major contributing factor in reducing ventricular performance results from depression of myocardial contractility and that this can be reversed, or at least improved, by inotropic drugs.


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natural selection

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