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A) Definitive Infective Endocarditis
1) Pathological Criteria
• Micro organism: demonstrated by culture or histology in a vegetation; or in a vegetation that has embolized, or in an intra cardiac abcess, or • Pathological lesions: vegetation or intracardiac abscess present, confirmed by histology showing active endocarditis.
2) Clinical Criteria, using specific definitions listed below:
• Two major criteria, or • One major and three minor criteria, or • Five minor criteria.
B) Possible Infective Endocarditis
• One major +1 minor or 3 minor.
C) Rejected
• Firm alternative diagnosis for manifestations of endocarditis, or • Sustained resolution of manifestations of endocarditis, with antibiotic therapy for 4 days or less, or • No pathological evidence of infective endocarditis at surgery or autopsy, after antibiotic therapy for 4 days or less.
Role of cell death As development of the limb proceeds waves of death or necrosis of large masses of mesodermal cells occur in certain regions at different stages. This has be
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