Discuss how the blood sugar level is maintained at a stable level in the well fed and fasting state

In  the fed state, clearance of blood  glucose is mainly by  liver via glucokinase. Further, uptake of glucose also takes place  in  the extra-hepatic tissues  (such as muscle,  idipose  tissue etc) favoured by  insulin. These two mechanisms regulate the blood glucose level in the fed state. While in the fasting state, glucose release from  the  liver increases due  to the action of glucagon and  in  the muscle  by epinephrine.