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Q. How does the inflammation mechanism work?
When some tissue injury other vasoactive and occurs histamine substances (called mediators of inflammation) are released, they cause the blood flow and vasodilation to the affected site increases. Granulocyte leukocytes present in the blood are attracted to the site of the injury by substances called as chemotactic factors also released by the injured tissue and by the active granulocytes in the area. The granulocytes exit the capillaries by diapedesis that is using pseudopods and Macrophages present in the region are activated too. These cells flood the extracellular space of the affected area trying to eliminate or kill harmful agents, to prevent to isolate and tissue necrosis the damaged tissue.
Synthesis of Polyamine As the name of this class of compounds suggests, polyamines have several amino groups replacing hydrogen usually in alkyl chain e.g., putrescine is 1, 4
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