How Complement System Helps To Handle Microbial Invasion

1)  Some components of a complement system coat microorganisms. These organisms with such a coat can be easily phagocytosed because of the receptors, which are similar for the same complement components which coat the microorganisms.

2)  Some component of the system stimulates the lethal mechanisms of phagocytes released earlier. They also release histamine and several other useful substances from mast cells and basophil granules. The major effects of granule release are vasodilatation and chemotactic migration of neutrophils and eosinophils to the site of infection.

3)  The complement pathway leads to the formation of membrane attack complex which stabs a hole into the microbial cell wall which would lead to the entry of water and Na+ ions into microbial cells leading to its lysis.