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In a unicellular organism, the interior region of the organism is no longer in contact with the external environment. Thus simple processes of diffusion, phagocytosis, exocytosis and contact with sea water helped in exchanging the necessary molecules and nutrients. But a further increase in size and complexity of the organism lead to concentration of the pool of cytoplasm. The fluid in-between the cells was known as interstitialfluids.
These fluids, due to constant exchange of molecules between the various cells lead to changes in the internal environment which influenced the functioning of the cell. Physiology, we learnt earlier, is concerned with such basic activities as reproduction, growth, metabolism, excitation and contraction as they are carried out within the fine structure - the cells, tissues, organs and organ systems of the body. The various body systems of our body are enumerated next.
Water-mill in Golden era: The water-mills were also invented in the classical period. But they came to be widely used only in the Middle Ages. The wind-mills and water-mills
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