How are the change in the ageing lens occurred in the metabolism?

Changes in the Ageing Lens

1) Physical changes: Lens weight increases, light transmission decreases, light scattering increases, fluorescein property increases and refractive index increases with age.

2) Metabolic changes: Proliferative capacity of lens decreases, many enzymes decreases, and insoluble albuminoids increases, glutathione decreases along with ascorbic acid, superoxide dismutase and glucose 6 phosphate dehydrogenase decreases.

3) Changes in the crystallins: Alpha and gamma crystallins decreases. Along with this gamma crystallins has a disulphide bond a11d increase in bela and non-tryotophan fluorescence.

4) Changes in plasma membrane and cytoskeleton.

5) There is loss of hexagonal cross linkage of fibres. Membrane protein and lipids are decreased. All the large membrane polypeptides are reduced along with changes in membrane rigidity.