How aggregation occur in sickle-cell anemia, Biology

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How does aggregation occur in sickle-cell anemia? Place the steps in the correct order from no aggregation to sickle red blood cell. Note that deoxyhemoglobin is generally in the T state; oxyhemoglobin is in the R state.


Additional T state HbS interact with the growing aggregation to form an insoluble fiber.

Val interacts with the "pocket" of a beta chain on another HbS.

R state Hb shifts to T state Hb

O2 decreases due to vigorous exercise or high altitude.


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