Hirschsprungs disease, Biology

Assignment Help:

Hirschsprungs Disease (Congenital Megacolon):

This  is also known as congenital megacolon. There is absence of ganglion cells, submucus plexus  and intramural plexus  (parasympathetic ganglion cells)  in distal segment usually rectosegmoid  junction. Incidence  is one in 5000  live birth.  

It is more common in males  than in females. 

In Hirschsprungs Diseasefthere is an arrest in embroylogic development affecting the migratioon  of parasympathetic nerves (innervation) of  the intestine occuring before 12 weeks of gestation due to genetic cause. This leads to the functional obstruction of the colon due  to  lack of peristalsis  in this area  leading  to  the accumulation of feces and gas proximal to the area of defected part. Due to accumulation of feces the colon becomes distended  so  the condition  is called as megacolon.

Nursing Assessment:

Neonate will present with failure to pass meconium and abdominal distention within a day or two after birth and if  rectal examination is done by  little finger there will be an explosive leakages of accumulated meconium and gas. There may be weight loss and dehydration due to bile-stained vomiting as a result of obstruction and failure to take fluid. Neonate may develop shock. Older childern will present with obstinate constipation with abdominal distention undernutrition and anorexia. There may be diarrhoea alternating with constipation due to bacterial action which liquefies the stool. The fecal mass can be palpated in left lower portion of  abdomen and rectal examination shows empty rectum. Diagnosis is supported by barium enema which shows constricted portion of aganglionic bowel distal to the dilated part of colon and diagnosis is confirmed by rectal biopsy which shows absent ganglion cells in submucosa and intermusular plexus with or without increased number of  nerve fibres.     


Related Discussions:- Hirschsprungs disease

Explain about the pregnancy and obesity, Explain the Pregnancy and Obesity?...

Explain the Pregnancy and Obesity? Obesity is associated with increased risk for gestational diabetes, hypertension, pre- eclampsia, perinatal mortality and the need for induce

Explain advantages of using yeast as a source of protein, Organism:- Yeast ...

Organism:- Yeast Advantages Large size, hence separation from the culture medium is easy.  As the pH of the growth is towards acidic side, high amount of lysine is prod

What are complementary genes, What are complementary genes? Does this inher...

What are complementary genes? Does this inheritance pattern obey Mendel's second law? Complementary genes are the different genes that act together to determine a given phenoty

What are brief descriptions test hypothesis, What are brief descriptions of...

What are brief descriptions of how you could test hypothesis. or how would you know if your hypothesis is testable?

Explain the use of spectinomycin in pregnancy, Use of Spectinomycin in Preg...

Use of Spectinomycin in Pregnancy  Spectinomycin (Trobicin) can be used to treat pregnant women allergic to beta-lactam antibiotics, but is unreliable against pharyngeal gonoco

What do you mean by age pyramids, Q. What are age pyramids? Age pyramid...

Q. What are age pyramids? Age pyramids are the graphical representations in form of superposed rectangles each representing the number of individuals included in age ranges int

Define why the virginia opossum is considered a generalist, Define why the ...

Define why the Virginia opossum is considered a generalist and the koala is considered a specialist. The opossum feeds on almost anything, whereas the koala feeds only on the l

Carditis, It has been shown by prospective studies that Rheumatic heart dis...

It has been shown by prospective studies that Rheumatic heart disease (RHD) is linked to the occurrence of carditis during the first episode of ARF. If the first episode is accompa

Variations, VARI A TION S - Defined as "dissimilarities of featur...

VARI A TION S - Defined as "dissimilarities of features among members of the same species". Offsprings of same parent are different and also differ from their parent.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd