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Higher criticism is a multiple-comparison test concept arising from the situation where there are number of independent tests of significance and interest lies in the rejecting joint null hypothesis.
The fraction of the observed significances at the given α-level is compared to the expected fraction under the joint null and the difference between the two quantities is standardized and this standardized value then maximized over the range of significance levels to provide the higher criticism statistic. This statistic is efficient in assessing whether n normal means are all zero against the alternative that the small fraction is nonzero.
Blinding : A procedure used in clinical trials to get rid of the possible bias which might be introduced if the patient and/or the doctor knew which treatment the patient is receiv
Multicentre study : The clinical trial conducted simultaneously in the number of participating hospitals, with all centres following an agreed-upon study of the protocol and with
Missing values : The observations missing from the set of data for some of the reason. In longitudinal studies, for instance, they might occur because subjects drop out of the stud
Chi-squared distribution : It is the probability distribution, f (x), of the random variable de?ned as the sum of squares of the number (v) of independent standard normal variables
Persson Rootze ´n estimator is an estimator for the parameters in the normal distribution when the sample is truncated so that all the observations under some fixed value C are re
Random allocation is a technique for creating the treatment and control groups particularly in accordance of the clinical trial. Subjects receive the active treatment or the place
The total amount of protein produced by a dairy cow can be estimated from periodic testing of her milk. The following are the total annual protein production values (lb) for 28 tw
Multiple imputation : The Monte Carlo technique in which missing values in the data set are replaced by m> 1 simulated versions, where m is usually small (say 3-10). Each of simula
The function of a variable t which, when extended formally as a power series in t, yields factorial moments as the coefficients of the respective powers. If the P(t) is probability
Monty Hall problem : A apparently counter-intuitive problem in the probability which gets its name from the TV game show, 'Let's Make a Deal' hosted by the Monty Hall. On show a pa
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