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Higher criticism is a multiple-comparison test concept arising from the situation where there are number of independent tests of significance and interest lies in the rejecting joint null hypothesis.
The fraction of the observed significances at the given α-level is compared to the expected fraction under the joint null and the difference between the two quantities is standardized and this standardized value then maximized over the range of significance levels to provide the higher criticism statistic. This statistic is efficient in assessing whether n normal means are all zero against the alternative that the small fraction is nonzero.
Population averaged models are the models for kind of clustered data in which the marginal expectation of response variable is the main focus of interest. An alternative approach
Last observation carried forward is a technique for replacing the observations of the patients who drop out of the clinical trial carried out over a time period. It consists of su
Histogram is the graphical representation of the set of observations in which class frequencies are represented by the regions of rectangles centred on the class interval. If the f
Hello-goodbye effect : The phenomenon initially described in psychotherapy research, but one which might arise whenever a subject is assessed on two occasions, with some interventi
Case-control study : The traditional case-control study is the common research design in the epidemiology where the exposures to risk factors for cases (individuals getting the dis
Ask quesoil company is considering whether or not to bid for an offshore drilling contract. If they bid, the value would be $600m with a 65% chance of gaining the contract. The com
Comparative exposure rate : A measure of alliance for use in a matched case-control study, de?ned as the ratio of the number of case-control pairs, where the case has greater expos
#ques12. There is some evidence that REM sleep, associated with dreaming, may also play a role in learning and memory processing. For example, Smith and Lapp (1991) found increased
Clinical trials : Medical experiments designed to assess which of two or more treatments is much more effective. It is based on one of the oldest philosophy of the scienti?c resear
what are tests for residual with nonconstant variance in regression diagnostic checking?
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