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If glycogen degradation and glycogen synthesis were allowed to occur concurrently, the net effect would be hydrolysis of UTP, a so-called futile cycle. To stop this, both pathways need to be strongly controlled. This control is carried out by allosteric regulation and covalent modification of both the glycogen phosphorylase and synthase. Additionally, the covalent modification is under close hormonal control.
Figure: Simultaneous operation of glycogen synthesis and degradation would result in net hydrolysis of UTP.
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