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It is an informal method of assessing the effect of the publication bias, generally in the context of the meta-analysis. The effect measures from each of the reported study are plotted on the x-axis against the corresponding sample sizes on y-axis. Because of nature of sampling variability this plot should, in the nonexistence of publication bias, have the shape of the pyramid with a tapering 'funnel-like' peak. Publication bias will tend to skew pyramid by selectively not including studies with small or no significant effects. Such studies predominate when sample sizes are small but are increasingly less ordinary as the sample sizes increase. Thus their absence removes part of the lower left-hand corner of the pyramid. This effect is illustrated in the Figure which is drawn below.
Protocol is the formal document outlining the proposed process for carrying out the clinical trial. The basic features of the document are to study the objectives, patient selecti
The approach to statistics based on a frequency view of probability in which it is supposed that it is possible to consider an in?nite sequence of the independent repetitions of th
A radically different approach of dealing with the uncertainty than the traditional probabilistic and the statistical methods. The necessary feature of the fuzzy set is a membershi
A term usually used for unobserved individual heterogeneity. Such variation is of main concern in the medical statistics particularly in the analysis of the survival times where ha
This is an alternative to the Newton-Raphson technique for optimization (finding out the minimum or the maximum) of some function, which includes replacing the matrix of second der
Maximum likelihood estimation is an estimation procedure involving maximization of the likelihood or the log-likelihood with respect to the parameters. Such type of estimators is
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Contour plot : A topographical map drawn from data comprising observations on the three variables. One variable is represented on horizontal axis and the second variable is represe
Graduation is the term is employed most often in the application of the actuarial statistics to denote procedures by which the set or group of observed probabilities is adjusted t
Higher criticism is a multiple-comparison test concept arising from the situation where there are number of independent tests of significance and interest lies in the rejecting jo
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