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The fundamental contractile unit is the sarcomere. Each muscle cell apart from the nucleus, mitochondria and other structures contains parallel fibrils. Sarcomere is a subunit of the fibril. It consists of parallel actin and myosin filaments. The thin actin filaments are attached to its limiting membrane or the Z line and interdigitates with the thicker myosin filaments which are placed centrally. The myosin filaments have flexible heads which can come into contact with the actin filaments. The filaments are propelled past each other by the repeated making and breaking of cross bridges between the actin and myosin filaments. In the resting state when the calcium level is low the myosin binding sites on the actin filament are blocked by tropomyosin which is a regulatory protein. This prevents cross bridge formation. When there is activation and a rise in calcium, the myosin actin binding sites are exposed. The energy required for the cross bridge recycling is provided by adenosine tripshophate (ATP). The number of cross bridges depends on the available calcium molecules. The greater the number of bridges, the more forceful the resulting contraction. During systole there is a 50 fold increase in intracellular calcium concentration.
Canine distemper Canine distemper, a highly contagious disease of dogs, is caused primarily by air- borne virus which belongs to the genus Morbillivirus in family Paramyxoviri
Sphaerosome Also known as Plant lysosome , because they contain hydrolytic enzymes. Hanstei n first observed them and called microsomes . Discovered by Dangeared
Complete feed blocks For manufacturing the pellets, processes such as grinding, mixing, steaming and pressing and some times extruding, are applied using special and expensive
Determine what the abnormal levels of AFP signal Abnormal levels of AFP may signal the following: Open neural tube Defect (ONTD) Down syndrome Other chromosoma1
Although fructose does not have an aldehyde group it reacts first of all bonds of fructose was breaked by fehling solution then fructose coverted to aldehydic group then that
How has the importance of the brain evolved from fishes to reptiles? From the least to the most difficult brain structure, it is evident that the brain, from fishes to beings o
Indications for Surgery : Once diagnosis of constrictive pericarditis is made and confirmed by chest X-ray, ECG, echocardiogram, CT, MRI scan, cardiac catheterisation and angio,
Q. How different are the concepts of neoplasia, tumor and cancer? Not all tumor is neoplastic and not every neoplasia creates tumor. The Tumor is the generic name given to the
How do the repairing enzymes of the genetic system act? There are enzymes inside the cells that detect errors or alterations in DNA molecules and begin a repair of those errors
Measles Adults born after 1956 who have not received 2 doses of live measles vaccine (not the killed vaccine that was commonly used in the 1960s) after their first birthday an
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