Find which two amino acids make up this pocket, Biology

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Sickling occurs in deoxyhemoglobin, but not in oxyhemoglobin. Normal deoxyhemoglobin (HbA and HbS) molecules have a small hydrophobic "pocket" on the surface of a ? chain. In oxyhemoglobin, however, this pocket is located toward the interior of the hemoglobin molecule. From what you know about the sickle-cell mutation and disease, determine which two amino acids make up this pocket.

1. Valine

2. Glutamate

3. Glutamine

4. Phenylalanine

5. Lysine

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