Find out pathway information about the proteins, Biology

Assignment Help:

Biopathways

1. Find out pathway information about these proteins using the Human Reactome.

O00327

O14503

O75586

O95096

P01137

P01308

P06744

P08240

P12236

P20309

P24863

P29966

P49336

P52945

Q07869

Q15648

Q16526

Q9UK39

O15055

Q9BTT4

a) Pathway Analysis - ID mapping and pathway assignment

How many proteins belong to the circadian clock pathway? Name two other pathways which these proteins are involved in?

b) Pathway Analysis - Overrepresentation analysis

List the top level pathways in order of significance?

What is the total number of proteins curated in the Diabetes pathway?

How many of the above list of proteins are present in the Diabetes pathway?

c) Describe the essential features of another Reactome tool.

2. Search for O15055 and P49336 in the IntAct database, explore the interactions for this proteins.

a) List the proteins O15055 interacts with giving details of the Interaction Detection Method and Publication for one of the proteins.

b) Using P49336, click on Graph to visualise the interactions of this protein then Open this network in Cytoscape.

Copy the IntAct graph or Cytoscape network in your answer.

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