Factors affects oxygen dissociation curve -organic phosphate, Biology

Assignment Help:

Factors affects Oxygen Dissociation Curve -Organic Phosphate

The presence of organic phosphates in the red blood cells helps to explain many peculiarities of the oxygen dissociation curve. Previously the red blood corpuscle was considered to be a bag full of haemoglobin with no metabolism of its own because of the absence of a nucleus. Now we know that it has an active carbohydrate metabolism and RBC has high content of ATP and 2,3-diphosphoglycerate (DPG). 2, 3-DPG is a product of glycolysis and it binds to P chain of the globin and reduces oxygen affinity.

Experimentally it was shown that pure haemoglobin has greater oxygen affinity than whole blood (the dissociation curve for pure haemoglobin is far to the left of the curve for whole blood). If 2, 3-DPG is added to pure haemoglobin solution the oxygen affinity decreases and approaches that of whole blood. The effect of 2,3-DPG is also important in transfer of oxygen from maternal to foetal blood. Foetal haemoglobin is different from adult haemoglobin in having 2 6 chains instead of P chains. Foeta haemoglobin therefore cannot bind to 2, 3-DPG and thus has higher affinity for oxygen at a given Po2. This higher oxygen affinity in foetal blood facilitates oxygen transfer from mother to foetus.


Related Discussions:- Factors affects oxygen dissociation curve -organic phosphate

Carrier based gutta percha removal -therma-fill, Carrier Based Gutta percha...

Carrier Based Gutta percha Removal “therma-fill” If the cone the carrier is metal and has cutting flutes that are engaging lateral dentin the instrument retrieval system (IRS)

Protein digestion, Protein Digestion Enzymes that digest proteins are ...

Protein Digestion Enzymes that digest proteins are divided into two groups endopeptidases and exopeptidases according to site of their action in the protein molecule. Endopept

Food-borne zoonoses, Food-borne zoonoses Food-borne illnesses are seri...

Food-borne zoonoses Food-borne illnesses are serious public health problem. They are associated with the ingestion of contaminated foods by microorganisms and their toxins, ma

Explain adverse effects of famciclovir, Adverse Effects of Famciclovir ...

Adverse Effects of Famciclovir Famciclovir has been generally well tolerated. Headache, nausea and diarrhea have been reported. Like acyclovir, famciclovir has been associated

Define neural and neurotransmitter control, Q. Define Neural and Neurotrans...

Q. Define Neural and Neurotransmitter Control? Coronary arteries are richly innervated by adrenergic and parasympathetic nerves. Both alpha 1 and alpha 2 adrenergic receptors a

In which layer of skin are follicles usually found, 1. In which layer of sk...

1. In which layer of skin are follicles usually found? 2. How are sebaceous glands associated with hair follicles? 3. In which layer of skin are sweat glands usually located?

Mulluscas., economic importance of mulluscas

economic importance of mulluscas

Define food quality factors and their measurement, Define Food quality fact...

Define Food quality factors and their measurement? Appearance; textural, flavour, nutritional, sanitary and keeping factors; quality standards, objective and organoleptic evalu

Which functional groups cannot react with each other, Which of the followin...

Which of the following pairs of functional groups CANNOT react with each other by a dehydration reaction? Select one: a. Carboxyl;Hydroxyl b. Carboxyl;Sulfhydryl c. Pho

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd