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Explain what is Genetic Factors ?
It has been suggested that certain genetic defect(s) could be partly responsible for increased risk of CAD in Asian Indians. No specific genetic defect has yet been identified butan excess prevalence or activation of the so-called 'thrifty' or pig-out gene [B3 subunit of heteromeric G protein (GNB3)l may be responsible for the development of obesity and metabolic syndrome when coupled with absence ofregular exercise (gene-environment interaction) - ultimately leading to Cardiovascular diseases. Ethnicity is a strong surrogate for this gene-environment interaction and may underlie the propensity to develop obesity and CVD due to natural selection of the 'thrifty' gene. Genetic predisposition may also be related to the Lipoprotein a (Lp-a), an atherogenic lipid fraction whose level is geneticallyDetermined and is found to be higher in Indians.
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