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Venous Thromboembolism
Prolonged immobilization (>8 hours) increases the risk of lower extremity deep vein thrombosis (DVT), particularly in travelers with risk factors for thrombosis. Nevertheless, flight-related symptomatic pulmonary embolism is rare.To minimize the risk, travelers should be advised to walk around or exercise while sitting by flexing/extending ankles and knees, to drink plenty of fluids and to avoid alcohol. Compression stockings can decrease the risk of asympto- matic DVT. One study found that giving a single dose of a low-molecular-weight heparin or aspirin as pro- phylaxis to travelers at high risk (past history of thrombosis, obesity, malignancy, increased platelets) reduced the incidence of DVT, but there is little evidence supporting this approach.
Ritonavir (RTV, Norvir) Ritonavir is well absorbed from the gastrointestinal tract and at full doses potently inhibits HIV, but due to poor tolerability it is now used mainly
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