Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Explain the Functions of Folate?Folate, also known as folic acid, is essential for good health. Folate requiring reactions include those involved in phases of amino acid metabolism, DNA (purine and pyrimidine) biosynthesis and the formation of the primary methylating agent, S-adenosyl methionine (SAM) as shown in Figure. Folate is involved in the de novo synthesis of purines (adenine and guanine), requiring the folate form, 10-formyl tetrahydro folic acid (THF), which is produced from 5, 10-methylene THF reactions catalyzed by the enzyme THF synthetase. The 510- methylene THF molecule has several fates, one of which is the reconversion to 5- methyl THF, catalyzed by methylene tetra hydrofolate reductase (MTHFR). Thus, folate in its reduced and polyglutamylated forms is essential for the DNA biosynthesis cycle, as shown in Figure. This conversion (5, 10-methylene THF molecule reconversion to 5-methyl THF) forms methionine from homocysteine. Folate, specially helps in reducing the risk of heart disease and stroke by lowering the level of the amino acid homocysteine in the blood (by forming methionine). At high levels, homocysteine can damage coronary arteries or make it easier for blood clotting cells to clump together and form a clot. This can increase the risk of heart attack or stroke. This methylation reaction (refer to Figure) requires the enzyme methionine synthase, cobalamin (vitamin BIZ) and 5-methyl THF. A methyl group is removed from 5 methyl THF and is sequentially transferred first to cobalamin coenzyme and then to homocysteine forming methionine and reconverting 5-methyl THF to tetrahydrofolate (THF). The dependency of methionine synthase on both folate and cobalamin explains why a single deficiency of either vitamin leads to the same megaloblastic changes in the bone marrow and other tissues, with rapidly dividing cells. Alternatively 5, 10-methylenetetrahydrofolate can be channelled to the methylation cycle (refer to Figure). This cycle has two functions. It ensures that the cell always has an adequate supply of S-adenosylmethionine (SAM), an activated form of methionine which acts as a methyl donor to a wide range of methyltransferases. The methyltransferases methylate a wide range of substrates including lipids, hormones, DNA and proteins. One particularly important methylation is that of myelin basic protein, which acts as insulation for nerve cells. When the methylation cycle is interrupted, as it is during vitamin BIZ deficiency, one of the clinical consequences is the demyelination of nerve cells resulting in a neuropathy which leads to ataxia (lack of coordination), paralysis, and, if untreated, ultimately death. Other important methyltransferase enzymes down-regulate DNA and suppress cell division.
Exercises and ambulation Continue taking all exercises taught in the hospital. Steam inhalation may be continued. Walk on levelled space first, gradually increase the dista
Explain about the Microbiological Study of Water? Water is the basic need of life. River, streams and underground water is the prime source for water. However, disposal of indu
is thare any excretory system found in echinoderms
Angiotensin Converting Enzyme Inhibitors (ACEI) has shown to reduce mortality in heart failure to the tune of 16-30 per cent in various large trials. The renin-angiotensin-aldos
I usually study in the library on the schools computers so I will be accessing the eBook from many different computers throughout the semester. Is there a limit to how many compute
Q. Echinoderm identity card. How are echinoderms characterized according to examples of representing beings, basic morphology, type of symmetry, germ layers and coelom, respiratory
Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4
Q. What are the Signs of cardiac tamponade? The clinical presentation will be that of a low output state with anxiety, restlessness, dyspnoea, sweating, cold extremities and dr
Benefits of diet modification are: 1) Control of sugar. 2) Control of weight. 3) Control of blood pressure. 4) Control of lipid profile. 5) Good health and well bei
Define Regents for Estimation of Reducing Sugar by Fehling Soxhlet Method? Fehling A solution - copper sulphate solution Fehling B solution - alkaline tartarate so
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +1-415-670-9521
Phone: +1-415-670-9521
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd