Explain the fluoride toxicity, Biology

Assignment Help:

Explain the Fluoride Toxicity?

Fluoride is a cumulative toxin. Ingestion of fluoride 1.0-1.5 mg/L for several years may produce dental fluorosis, i.e. browning and pitting of teeth known as mottling, as you may recall studying in the Public Nutrition Course (MFN-006). Chronic high level of fluoride in the range of 2-5 mgL can cause skeletal fluorosis. Crippling skeletal fluorosis can occur where drinking water containing higher than 10 mg/L is consumed over several. years. The severe forms of skeletal deformity in toxic fluorosis include kyphosis (abnormal curvature of the spine), fixed spine and other joint deformities. Hyper parathyroidism secondary to high fluoride intake has been reported, which induces calcification of soft tissues. You may recall that PTH is a hormone involved in calcium homeostasis, releasing calcium from the bone into the blood when blood calcium levels tend to fall. An abnormal increase in PTH can add calcium to the soft tissues, hardening them in the process.

A form of severe skeletal flourosis known as "Genuvalgium" (knocked knees) has been reported from part of India, China and African countries. The condition is characterized by severe skeletal fluorosis and osteoporosis of the limbs. Chronic ingestion of excess fluoride coupled with low calcium and high molybdenum intakes appear to increase fluoride retention in the bone. While hyper-parathyrodism and increased levels of PTH result in calcium removal from the bone, explaining the osteoporosis of the limbs.


Related Discussions:- Explain the fluoride toxicity

Mollusca, Order of classification

Order of classification

Dietetic foods for diabetes, Dietetic Foods for diabetes: With advances...

Dietetic Foods for diabetes: With advances in food technology, foods for special use by diabetics are now available in the global market, they are emerging in India also. These

Define fats required for underweight - nutritional care, Define Fats requir...

Define Fats required for underweight - nutritional care? Fats: We know that fats are concentrated source of energy (lg = 9 Kcals). Fats are capable of increasing the energy val

Tallness trait of a pea plant, What is the tallness trait of a pea plant mo...

What is the tallness trait of a pea plant moving separately from the color trait an example of? This is an instance of Mendel's second law, the Law of Independent Assortment, w

Explain the rapport building, Q. Explain the Rapport Building? Maintain...

Q. Explain the Rapport Building? Maintaining good relationship with the client is very important in counselling. This will help you to gain trust, confidence of the client and

Scientific method, SCIENTIFI C METHOD - The scientific approach to exp...

SCIENTIFI C METHOD - The scientific approach to explain a particular phenomenon require a series of organized steps based on common sense. It is called scientific method. A

Disinfectant, General information about disinfectants A disinfectant is...

General information about disinfectants A disinfectant is a chemical that kills disease-causing agents on contact. Natural disinfection agents, such as sunlight, heat, keeping

Fertilisation, Explain how the uterus supports the development of a baby du...

Explain how the uterus supports the development of a baby during gestation

Design of expression vectors in transgenic animals, D esig n of expressio...

D esig n of expression vectors Expressing a transgene in an appropriate manner is a huge task. The gene construct that is quite active in transfected cells may be only weakl

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd