Explain the fluoride toxicity, Biology

Assignment Help:

Explain the Fluoride Toxicity?

Fluoride is a cumulative toxin. Ingestion of fluoride 1.0-1.5 mg/L for several years may produce dental fluorosis, i.e. browning and pitting of teeth known as mottling, as you may recall studying in the Public Nutrition Course (MFN-006). Chronic high level of fluoride in the range of 2-5 mgL can cause skeletal fluorosis. Crippling skeletal fluorosis can occur where drinking water containing higher than 10 mg/L is consumed over several. years. The severe forms of skeletal deformity in toxic fluorosis include kyphosis (abnormal curvature of the spine), fixed spine and other joint deformities. Hyper parathyroidism secondary to high fluoride intake has been reported, which induces calcification of soft tissues. You may recall that PTH is a hormone involved in calcium homeostasis, releasing calcium from the bone into the blood when blood calcium levels tend to fall. An abnormal increase in PTH can add calcium to the soft tissues, hardening them in the process.

A form of severe skeletal flourosis known as "Genuvalgium" (knocked knees) has been reported from part of India, China and African countries. The condition is characterized by severe skeletal fluorosis and osteoporosis of the limbs. Chronic ingestion of excess fluoride coupled with low calcium and high molybdenum intakes appear to increase fluoride retention in the bone. While hyper-parathyrodism and increased levels of PTH result in calcium removal from the bone, explaining the osteoporosis of the limbs.


Related Discussions:- Explain the fluoride toxicity

Can high blood pressure cause coronary sclerosis, Q. Can High blood pressur...

Q. Can High blood pressure cause coronary sclerosis? High blood pressure causes coronary sclerosis (hardening in early stages, fatty lesions in the inner surface of [he artery

Pylum mollusca, Economic importance of phylum mollusca

Economic importance of phylum mollusca

Formula concentration and supplementation - calorie density, Define Formula...

Define Formula Concentration and Supplementation - Calorie Density? Formula Concentration can be done by decreasing the amount or water added in the mixing of the formula. Sta

Regulatory mechanisms, Normal 0 false false false EN-IN...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Mode of nutrition, What is the mode of nutrition of Ascaris?

What is the mode of nutrition of Ascaris?

Define growth studies for studying nutrient requirement, Define Growth Stud...

Define Growth Studies for studying Nutrient Requirement? Nutrient requirements of infants and young children are estimated by studying the rate of growth of healthy children an

Osmosis, If you have water, 10% sucrose, and 40% sucrose solution. Which so...

If you have water, 10% sucrose, and 40% sucrose solution. Which solutions were isotonic to each other?

How does the intensity of facilitated diffusion differ, Q. How does the int...

Q. How does the intensity of facilitated diffusion differ in relation to the concentration of the moved substance? What is limiting factor? Like simple diffusion facilitated di

What is ATP which invovles in use/transfer of all cells, The use and transf...

The use and transfer of energy in all cells involves same compound, ATP. The letters ATP stand for chemical: a) Adenosine triphosphate b) Aluminum trioxide c) Atrophine t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd