Explain the absorption, storage and elimination of folate, Biology

Assignment Help:

Explain the Absorption, Storage and Elimination of Folate?

Folic acid is readily absorbed from the small intestines through the portal vein and  passed onto the tissues through general circulation. Naturally occurring food folate is converted into the monoglutamate form by the enzyme pteroylpolyglutarnate  hydrolase or folate conjugase or glutamate carboxypeptidase II, located in the  jejunal brush border membrane. After de conjugation, the monoglutaniyl folate is transported across the membrane by a pH-dependent carrier-mediated mechanism.

Folic acid once absorbed is acted upon by hepatic dihydrofolate reductase to convert to its metabolically active form which is tetrahydrofolic acid (THF). Following absorption, folic acid is largely reduced and methylated in the liver to 'N-5 methyltetrahydrofolic acid, which is the main transporting and storage form of folate in the body. Folate transport across membranes into cells in kidney, placenta and choroid plexus, occurs via membrane-associated folate binding proteins that act s folate receptors and facilitate cellular uptake of folate. Larger doses of folate may escape metabolism by the liver and appear in the blood mainly as folic acid.


Related Discussions:- Explain the absorption, storage and elimination of folate

What are the differences between bacterial and eukaryotic, What are the dif...

What are the differences and similarities between the bacterial and eukaryotic cell membranes?

Use of echocardiography in pericardial diseases, Q. Use of echocardiography...

Q. Use of echocardiography in pericardial diseases? One of the earliest clinical applications of echocardiography was in the detection of pericardial effusion and it remains th

Describe the effects of the failure of the pancreas, (a) Name the condition...

(a) Name the condition and (b) describe the effects of the failure of the pancreas to produce sufficient-insulin. (c) How is this condition treated? .

Taxonomy, classification tree for pisces

classification tree for pisces

Significance of the uterine glycogen- producing glands, Q. What is the sign...

Q. What is the significance of the uterine glycogen- producing glands? The uterine glands produce glycogen that able to degrade into glucose to nourish the embryo before the co

Briefly explain lichens organism, Briefly explain Lichens organism? Lic...

Briefly explain Lichens organism? Lichens are unique organisms consisting of a symbiotic relationship between a fungus and a photosynthetic organism. They represent a type of s

Explain beef extract and yeast extract, Explain Beef Extract and Yeast Extr...

Explain Beef Extract and Yeast Extract These are aqueous extracts of lean beef and brewer's yeast, respectively. Beef extract provides amino acids, peptides, nucleotides, organ

What are presbyopia and astigmatism, What are presbyopia and astigmatism? ...

What are presbyopia and astigmatism? Presbyopia is the visual impairment in which there is loss of the cililary muscle strength therefore reducing the capability of the crystal

Carbon dioxide for photosynthesis, Aim: To prove that Carbon dioxide is ess...

Aim: To prove that Carbon dioxide is essential for photosynthesis. Apparatus: A potted healthy plant with long and narrow leaves, a wide mouthed glass bottle, split cork. Chemicals

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd