Explain the absorption, storage and elimination of folate, Biology

Assignment Help:

Explain the Absorption, Storage and Elimination of Folate?

Folic acid is readily absorbed from the small intestines through the portal vein and  passed onto the tissues through general circulation. Naturally occurring food folate is converted into the monoglutamate form by the enzyme pteroylpolyglutarnate  hydrolase or folate conjugase or glutamate carboxypeptidase II, located in the  jejunal brush border membrane. After de conjugation, the monoglutaniyl folate is transported across the membrane by a pH-dependent carrier-mediated mechanism.

Folic acid once absorbed is acted upon by hepatic dihydrofolate reductase to convert to its metabolically active form which is tetrahydrofolic acid (THF). Following absorption, folic acid is largely reduced and methylated in the liver to 'N-5 methyltetrahydrofolic acid, which is the main transporting and storage form of folate in the body. Folate transport across membranes into cells in kidney, placenta and choroid plexus, occurs via membrane-associated folate binding proteins that act s folate receptors and facilitate cellular uptake of folate. Larger doses of folate may escape metabolism by the liver and appear in the blood mainly as folic acid.


Related Discussions:- Explain the absorption, storage and elimination of folate

Explain genital herpes, Explain Genital herpes Acyclovir  (Zovirax,  a...

Explain Genital herpes Acyclovir  (Zovirax,  and others), famciclovir (Famvir) or valacyclovir (Valtrex) taken orally for 7-10 days shortens the duration of pain, viral sheddi

Chemical properties of carbohydrates, CHEMICA L PROPERTIES Monosacchar...

CHEMICA L PROPERTIES Monosaccharides have two special chemical properties (i) Reducing Nature. All the monosaccharides are reducing sugars. It can reduce Cu2

Explain procedure for the use of light microscope, Explain Procedure for th...

Explain Procedure for the use of Light Microscope? Now carry out the exercise following the steps enumerated herewith. 1. Place the microscopic slide with any specimen on th

Explain polio, Explain Polio Adults who have not previously been immuni...

Explain Polio Adults who have not previously been immunized against polio should receive a primary series of inactivated polio vaccine (IPV) if traveling to areas where polio i

Local control mechanism within the circulatory system, Which of the followi...

Which of the following is true for active hyperemia, a local control mechanism within the circulatory system? A. There will be an increase in force developed by smooth muscles

Data gathering - steps in nursing process, Data Gathering   It is the g...

Data Gathering   It is the gathering of information about client's physical heath, mental outlook, social circumstances, family and community life, and other factors. To p

Phytochrome - development of plant, Phytochrome - Development of plant ...

Phytochrome - Development of plant You know that plants capture light energy during photosynthesis, now you are familiarised with another important and interesting role of lig

What is hemoglobin, What is hemoglobin? What is the inorganic element that ...

What is hemoglobin? What is the inorganic element that is fundamental in the composition of hemoglobin? Hemoglobin is the protein present in the blood responsible for the trans

Basic domains of dna, DNA binding domains called as basic domains rich in b...

DNA binding domains called as basic domains rich in basic amino acids that was happen in transcription factors in combination with zipper helix-loop-helix or leucine (HLH) dimeriza

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd