Explain the absorption, storage and elimination of folate, Biology

Assignment Help:

Explain the Absorption, Storage and Elimination of Folate?

Folic acid is readily absorbed from the small intestines through the portal vein and  passed onto the tissues through general circulation. Naturally occurring food folate is converted into the monoglutamate form by the enzyme pteroylpolyglutarnate  hydrolase or folate conjugase or glutamate carboxypeptidase II, located in the  jejunal brush border membrane. After de conjugation, the monoglutaniyl folate is transported across the membrane by a pH-dependent carrier-mediated mechanism.

Folic acid once absorbed is acted upon by hepatic dihydrofolate reductase to convert to its metabolically active form which is tetrahydrofolic acid (THF). Following absorption, folic acid is largely reduced and methylated in the liver to 'N-5 methyltetrahydrofolic acid, which is the main transporting and storage form of folate in the body. Folate transport across membranes into cells in kidney, placenta and choroid plexus, occurs via membrane-associated folate binding proteins that act s folate receptors and facilitate cellular uptake of folate. Larger doses of folate may escape metabolism by the liver and appear in the blood mainly as folic acid.


Related Discussions:- Explain the absorption, storage and elimination of folate

Introduction of environment, BASICS OF ENVIRONMENT We live in two world...

BASICS OF ENVIRONMENT We live in two world one is natural world of animals, plants, air, water and soil that was present since the evolution of earth. The other world is of soc

Some common air pollutants: oxides of nitrogen, Oxides of nitrogen:   ...

Oxides of nitrogen:          These include nitrogen monoxide (NO) and nitrogen dioxide (NO2). NO is a colourless, odourless and inert gas but like CO it can also combine with

Classification, What is omnispective classification

What is omnispective classification

Summary of determinants of health status, Normal 0 false fals...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Define the potassium ion impermeability, At 1 AM, an impermeable membrane s...

At 1 AM, an impermeable membrane separates a 1 liter solution of 2M KCl in the left compartment from a 1 liter solution containing both 1M NaCl and 1M KCl in the right compartment.

Why is the aids treatment often done with a drug cocktail, Why is the AIDS ...

Why is the AIDS treatment often done with a drug cocktail? The treatment of acquired immune deficiency syndrome is often done with one or more anti-retroviral drugs of dissimil

Zoonoses disease-ehrlichiosis, Ehrlichiosis The disease is caused by a ric...

Ehrlichiosis The disease is caused by a rickettisia, called Ehrlichia canis. Dogs and man are the reservoir hosts. The infection is transmitted through bite of infected tick, Rhip

Species diversity - synthetic characters, Species Diversity - Synthetic Cha...

Species Diversity - Synthetic Characters It is one of the most important and basic characteristics of a community. There are various ways of measuring species diversity the si

Cartilage occur in a joint and what it its function, Where does cartilage o...

Where does cartilage occur in a joint and what it its function? Cartilage might be found covering the surface of bones where they meet in a movable joint. Cartilage decreases f

Factors limiting the productivity of aquatic habitats, Factors Limiting the...

Factors Limiting the Productivity of Aquatic Habitats Sunlight and oxygen are the two most important limiting factors of the aquatic ecosystems. This distinguishes them from t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd