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Explain The absorption of itraconazole capsules
It is decreased with concurrent use of drugs that reduce gastric acidity, such as antacids, H2-receptor blockers, proton pump inhibitors or didanosine (Videx).
Itraconazole is a potent inhibitor of the hepatic isozyme CYP3A4 and may enhances serum concentrations of drugs that are metabolized by this enzyme. For this reason, itraconazole is contraindicated with the following drugs: cisapride (Propulsid), dofetilide (Tikosyn), ergot alka- loids, levomethadyl (Orlaam), lovastatin, oral midazolam (Versed, and others), pimozide (Orap), quinidine, simvastatin, and triazolam (Halcion, and others). Itraconazole is itself also a substrate of CYP3A4; its metabolism may be affected by both inducers of the enzyme, such as rifampin and carbamazepine (Tegretol, and others), and by other inhibitors.
Outline the importance of buffer systems in the human body. In addition, describe the main biological buffer systems and how they function.
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