Explain the absorption of itraconazole capsules, Biology

Assignment Help:

Explain The absorption of itraconazole capsules

It is decreased with concurrent use of drugs that reduce gastric acidity, such as antacids, H2-receptor blockers, proton pump inhibitors or didanosine (Videx).

Itraconazole is a potent inhibitor of the hepatic isozyme CYP3A4 and may enhances serum concentrations of drugs that are metabolized by this enzyme. For this reason, itraconazole is contraindicated with the following drugs: cisapride  (Propulsid), dofetilide  (Tikosyn), ergot alka- loids, levomethadyl  (Orlaam),  lovastatin, oral midazolam (Versed, and others), pimozide  (Orap), quinidine, simvastatin, and triazolam (Halcion, and others). Itraconazole is itself also a substrate of CYP3A4; its metabolism may be affected by both inducers of the enzyme, such as rifampin and carbamazepine (Tegretol, and others), and by other inhibitors.

 


Related Discussions:- Explain the absorption of itraconazole capsules

Digestion, Adsk question #Minimum 100 words accepted#saliva enzyme

Adsk question #Minimum 100 words accepted#saliva enzyme

Nervous system - midbrain, MID BRAIN - Optics lobes 4 in number ( Corpo...

MID BRAIN - Optics lobes 4 in number ( Corpora Quadrizemmini ) in frog corpora bizemmini . Solid, optocoel is absent. 2 superior coculi and 2 inferior coculi are present.

Mrna levels and rna species, You are working at a large, well funded resear...

You are working at a large, well funded research institute with the latest biochemical techniques available. The focus of your research is to find a specific mutation, or set of mu

Why enzymes work to speed up a chemical reaction, Enzymes work to speed up ...

Enzymes work to speed up a chemical reaction by: a. attaching coenzymes to the substrate b. heating up the substrate c. lowering the activation energy of the reaction d. supplyi

Respiration, lesson plan practical requirements

lesson plan practical requirements

Arthropods, what are the general characteristics of arthropods?

what are the general characteristics of arthropods?

What is the parasite that causes toxoplasmosis, What is the parasite that c...

What is the parasite that causes toxoplasmosis? How is the disease transmitted and what are its typical manifestations? Toxoplasmosis is caused by the protozoan Toxoplasma gond

A light microscope with unlimited resolution, Theoretically you can build a...

Theoretically you can build a light microscope with unlimited magnification, but can you build a light microscope with unlimited resolution? Why or why not? (Hint: what really cont

Define drug effects on carbohydrate metabolism, Define drug effects on Carb...

Define drug effects on Carbohydrate metabolism? Carbohydrate metabolism: Hypoglycemic drugs such as insulin and sulphonylureas are prescribed because of their ability to increa

Crustacea, Crustacea The Crustacea show a great morphological diversit...

Crustacea The Crustacea show a great morphological diversity of appendages which may be grouped into three categories, cephalic, thoracic and abdominal. Their appendages are c

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd