Explain Rifamycins-Rifampin

Rifamycins - Rifampin, like isoniazid, is potentially hepatotoxic, and gas- trointestinal disturbances, morbilliform rash and thrombocytopenic purpura can happen. Whenever possible, rifampin should be continued despite minor adverse reactions like pruritus and gastrointestinal upset. When taken erratically, the drug can cause a febrile "flu-like" syndrome and, very often, shortness of breath, hemolytic anemia, shock and acute renal failure. Patients should be warned that rifampin may turn urine, tears and other body fluids reddish-orange and can permanently stain contact lenses and lens implants.