Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

Alkaline slant - carbohydrate utilization pattern test, Alkaline slant - Ob...

Alkaline slant - Observation for Carbohydrate Utilization Pattern Test Alkaline slant (red) and acid butt (yellow) with or without gas production - This indicates fermentation

What is the procedure of normal saline dressing, What is the Procedure of N...

What is the Procedure of Normal saline dressing 1. First collect the supplies near the patient. Place should be clean with good lighting where it is easy to work. Use a newspap

Glycolysis, Glycolysis Oxidation of glucose is called as glycolysis.Glu...

Glycolysis Oxidation of glucose is called as glycolysis.Glucose is oxidized to either lactate or pyruvate. Under aerobic conditions and the dominant product within most tissues

How can the presence, Q. How can the presence, function of muscular tissue ...

Q. How can the presence, function of muscular tissue and localization in beings of the phylum Annelida is explained? In these beings there are a longitudinal muscular layer und

Dideoxy sequencing, Dideoxy Sequencing is the enzymatic determination and ...

Dideoxy Sequencing is the enzymatic determination and consideration of DNA or RNA sequence by the rechnique of Sanger and colleagues, based on incorporation of the chain terminati

Cellular Respiration, what two gases are released by animals during the pro...

what two gases are released by animals during the process of cellular respiration

The permissible use of the technique amniocentesis, The permissible use of ...

The permissible use of the technique amniocentesis is for: 1. detecting sex of the unborn foetus 2. artificial insemination 3. transfer of embryo into the uterus of the su

Duration limit of the qrs, Q. Duration limit of the QRS? The duration o...

Q. Duration limit of the QRS? The duration of the QRS is usually reduced slightly during exercise. Because catecholamines increase conduction velocity in the Purkinje fibers an

What is the concentration of your new solution, You have 30 mL of a 1M sodi...

You have 30 mL of a 1M sodium monophosphate buffer and you dilute dilute it to a volume of 10L. What is the concentration of your new solution? I came up with 0.003M, does that see

Respiration would cease even oxygen and food were supplied, If a tissue was...

If a tissue was heated to 65ºC for 10 minutes, respiration would cease even if oxygen and food were supplied. Why is this? A temperature of 65°C for 10 minutes would denature

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd