Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

Genetic, Ask quesIn Cross 1, pure-breeding colored, starchy kernel plants (...

Ask quesIn Cross 1, pure-breeding colored, starchy kernel plants (C1Wx/C1Wx) were crossed to plants pure-breeding for colorless, waxy kernels (c1 wx/c1 wx). The F1 of this cross we

Epididymis, EPIDIDYMIS - All seminiferous tubules form short straigh...

EPIDIDYMIS - All seminiferous tubules form short straight tubules as tubuli recti, open into wider network of rete testis. From rete testis 15-20 fine convoluted tubules,

The outside of the neuron to the inside, Which of the following require ATP...

Which of the following require ATP? The movement of potassium from the outside of the neuron to the inside? The movement of sodium into the neuron through a chemically gated

What is aflatoxin, Q. What is Aflatoxin? Aflatoxins are the most widely...

Q. What is Aflatoxin? Aflatoxins are the most widely studied of all mycotoxins. Knowledge of their existence dates from 1960, when more than 100,000 turkey died in England afte

Structures of a flowering plant, Which structures of a flowering plant give...

Which structures of a flowering plant give rise to (a) potatoes, (b) the fleshy scales of an onion?   (a) A potato is a tuber formed at the end of an underground stem (b) O

Explain risk factors and their role in cad, Explain risk factors and their ...

Explain risk factors and their role in cad ? The concept of risk factors constitutes a major advance for developing strategies to prevent CVD. The Framingham Heat Study played

Rabbit femur, describe the features of the rabbit femur bone

describe the features of the rabbit femur bone

What is galactosemia, Q. What is Galactosemia? Galactosemia is a geneti...

Q. What is Galactosemia? Galactosemia is a genetic disorder caused by deficient functioning of any of these three enzymes namely galactokinase, galactose -1 - phosphate uridyl

Gastrulation in some animals, Gastrulation in some Animals As mentione...

Gastrulation in some Animals As mentioned before gastrulation marks the beginning of morphogenesis that is development of body form and organisation of cells in the embryo. By

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd