Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

Monitoring therapy for endocarditis, Within a week after initiation of effe...

Within a week after initiation of effective antimicrobial therapy, almost 75 per cent of patients with IE, including those with PVE, are afebrile and 90 per cent have defervesced b

Define prevention of idd - double fortified salt, Define prevention of idd ...

Define prevention of idd - Double Fortified salt? iron deficiency anaemia and iodine deficiency disorders often co-exist, the most effective approach to control these public he

Define fuel molecules and lipogenesis, Define Fuel Molecules and Lipogenesi...

Define Fuel Molecules and Lipogenesis? Lipogenesis is a collective name for the complex process of producing lipids (fatty acids) from smaller precursor molecules. The synthesi

Is the esophagus a muscular organ, Is the esophagus a muscular organ? Why e...

Is the esophagus a muscular organ? Why even in a patient lying totally flat on a hospital bed can the swallowed food reach the stomach? The esophagus is a predominantly muscula

Explain phenotypical characteristics of alleles of a gene, What are few exa...

What are few examples of phenotypical characteristics that present two or more varieties and of phenotypical features that do not vary? In relation to the genes correspondent to th

What is fluoride inhibitor, Fluoride Inhibitor Fluoride inhibits  enola...

Fluoride Inhibitor Fluoride inhibits  enolase enzyme involved in the conversion of 2-phosphoglerate  to phosphoenol pyruvate.

Define the integrity of gut or colon - dietary fiber, Define the Integrity ...

Define the Integrity of gut or colon? Dietary fibre especially fermentable fibres play an important role in maintaining the integrity of gut. SCFAs generated during fermentatio

Which are the structures that are part of the nervous system, Q. Which are ...

Q. Which are the structures that are part of the nervous system? The structures that form the nervous system can be divided into the peripheral nervous system (PNS) and the cen

Cell biology, explain in detail the cell theory and it exceptions

explain in detail the cell theory and it exceptions

What is the dna vaccine, Q. What is the DNA vaccine? The DNA vaccinatio...

Q. What is the DNA vaccine? The DNA vaccination or is a vaccination technology based on genetic engineering. In DNA vaccine a recombinant plasmid (vector) containing the gene o

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd