Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

Define about the photometry - colorimetry, Define about the Photometry - co...

Define about the Photometry - colorimetry? Photometry is the measurement of the luminous intensity light or the amount of luminous light falling on a surface from such a source

Several types of steam sterilizer, The several types of steam sterilizers t...

The several types of steam sterilizers that are in use. 1. Lab Autoclave 2. Hospital dressing sterilizer 3. Bowl & instrument sterilizer 4. Rapid cooling sterilizer

Describe nerve cells, In eukaryotes possibly the most rapid and complex sig...

In eukaryotes possibly the most rapid and complex signaling is mediated through nerve impulses.  The Nerve  cells  (neurons)  consist  of  a cell  body  with  numerous projections

Water loss - plant water relation, Water Loss - Plant Water Relation ...

Water Loss - Plant Water Relation Plants lose about 98% of water to the atmosphere by transpiration. Often water loss by transpiration exceeds gain by absorption and results

State in brief about the neuropsychological tests, State in brief about the...

State in brief about the Neuropsychological tests Neuropsychological tests have to be constructed using the psychometric approach the interpretation of test performance would n

What do you mean by recovery period, Q. What do you mean by Recovery Period...

Q. What do you mean by Recovery Period? At the instant exercise is discontinued, the ECG recorded is turned on and left running for a few seconds while the blood pressure is re

Define translation phase of gene expression process, Define Translation Pha...

Define Translation Phase of gene expression process? The NDA which the transcript into m RNA is translated into protein with the help of ribosomes, m RNA, amino acids, a number

Define hydrolytic rancidity - lipolysis, Define hydrolytic rancidity Li...

Define hydrolytic rancidity Lipolysis is a major action occurring during deep fat frying due to large amounts of water introduced from the food and the relatively high temperat

Deer, How does a deer feed

How does a deer feed

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd