Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

How can bacteria produce human insulin, How can bacteria produce human insu...

How can bacteria produce human insulin on an industrial scale? What are the other forms of insulin made available by the pharmaceutical industry? Bacteria do not naturally synt

Heart, Septa prevent oxygenated and deoxygenated blood. Give reason

Septa prevent oxygenated and deoxygenated blood. Give reason

Algal or planktonic fish poisonings, Algal or Planktonic Fish Poisonings: F...

Algal or Planktonic Fish Poisonings: Fish poisoning can result from the ingestion of fish or shellfish that have fed upon algae toxic to human beings. Paralytic shellfish poisoning

What is sporocyst. specify., What is Sporocyst? Specify. A stage in the...

What is Sporocyst? Specify. A stage in the life cycle of trematode flukes. Sporocyst develops from the mericidium found in intermediate host. Every sporocyst contains the germ

Explain karyotype - animal taxonomy, Explain Karyotype - Animal Taxonomy? ...

Explain Karyotype - Animal Taxonomy? In animals systematic, it is the karyotype, that is the chromosome number and structure which are used quite extensively either separately

Define class turbellaria - flatworms, Define Class Turbellaria - Flatworms ...

Define Class Turbellaria - Flatworms ? Members of these two Classes are known as the flukes. Flukes are parasitic flatworms that inhabit tropical areas like Southeast Asia and

Define termination phase - mechanism of protein synthesis, Define Terminati...

Define Termination phase - mechanism of protein synthesis? Termination: RNA polymerase recognizes the terminator, which results in no further nucleotides being incorporated and

What is critical photoperiod, What is critical photoperiod? And How can the...

What is critical photoperiod? And How can the critical photoperiod relate to flowering be experimentally determined? Critical photoperiod is the limit of the photoperiod durati

Define sterilization, Question 1 Write a short note on the following- ...

Question 1 Write a short note on the following- Fermenter Batch culture Viral pesticides Brewing   Question 2 Define sterilization. Discuss different ty

Sexual reproduction, SEXUA L REPRODUCTION 1 .       Amphigony       ...

SEXUA L REPRODUCTION 1 .       Amphigony        -          Zygote is formed. (i) Syngamy Fusion of gametes. (a) Endogamy - It involves self fertilisation. e.g.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd