Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

Define the term - lateralisation and localisation, Define the term - latera...

Define the term - lateralisation and localisation Discriminative validity studies including lateralisation and localisation achieved satisfactory results, but the localisation

What are the main complications of diabetes mellitus, Why do diabetic patie...

Why do diabetic patients often undergo dietary sugar restriction? What are the main complications of diabetes mellitus? Diabetic patients are often advised to ingest fewer carb

Slight or no metamorphosis, Slight or no Metamorphosis In primitive w...

Slight or no Metamorphosis In primitive wingless insects (Apterygota) such as spring tails, silver fish etc. and in secondarily apterous insects the young ones which hatch fr

Korarchaeotes, what is the effect that korarchaeotes have on humans?

what is the effect that korarchaeotes have on humans?

Explain about pentoses, What are pentoses? To what organic group do pentose...

What are pentoses? To what organic group do pentoses belong? Are nucleotides formed of only one type of pentose? Pentoses are carbohydrates made of five carbons. Deoxyribose is

Gaseous exchange, Gaseous Exchange Gaseous exchange is take place on b...

Gaseous Exchange Gaseous exchange is take place on by both mantle and the gills. The gills of most bivalves are highly changed for filter feeding. They are derived from the pr

Why is blood significant for larger animals, What is the alternative means ...

What is the alternative means for transport of substances in animals without a circulatory system? Why is blood significant for larger animals? In animals that do not present t

Photosynthesis, how does the green plant build up carbohydrates

how does the green plant build up carbohydrates

Distribution of stomata, Distribution of Stomata There are two paramet...

Distribution of Stomata There are two parameters normally used for expressing the distribution of stomata. Stomatal frequency: The number of stomata per unit area

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd