Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

Difference between striated, DIFFERENCE S BETWEEN STRIATED, NON-STRIATED A...

DIFFERENCE S BETWEEN STRIATED, NON-STRIATED AND CARDIAC MUSCLE FIBRES -                      Striated                                                              Non-striat

Dna extraction, sir i want standard protocol to extract dna from banana le...

sir i want standard protocol to extract dna from banana leaves

Describe assist control ventilation, Describe Assist Control Ventilation (A...

Describe Assist Control Ventilation (ACV) The machine delivers a set tidal volume at the set rate; besides, each time the patient breathes on his own, a machine breath is init

Illustrate steps of polymerase chain reaction , There are three steps of PC...

There are three steps of PCR a) Denaturation.  The reaction combination is heated to 95°C for a short time period (about 15-30 sec) to denature the goal DNA into one strands w

What is the formula for calculation of bone distortion, What is the formula...

What is the formula for calculation of bone distortion The following formula can be used to calculate for distortion: Effective Bone available = Reference sphere diameter ×

Food-borne zoonoses, Food-borne zoonoses Food-borne illnesses are seri...

Food-borne zoonoses Food-borne illnesses are serious public health problem. They are associated with the ingestion of contaminated foods by microorganisms and their toxins, ma

fat digestion requires two steps, Fat digestion requires two steps? What a...

Fat digestion requires two steps? What are the steps and what enzymes are used to accomplish each step?

How to increase in sodium conductance, How to increase in sodium conductanc...

How to increase in sodium conductance A complete motor neuron is removed from a frog and placed in normal physiological saline at 1 AM.  The neuron is healthy.  At 2 AM, the ph

Microtubule assembly, Microtubule assembly: A) generally originates in the ...

Microtubule assembly: A) generally originates in the centrosome. B) occurs only during mitosis. C) occurs randomly throughout the cell. D) is regulated by myosin. E) is inhibited d

Sterility in angiosperms, Sterility in Angiosperms Sterility in angios...

Sterility in Angiosperms Sterility in angiosperms may arise due to several causes. Either the anther may not be formed, or anthers are formed but meiosis may be abnormal. A

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd