Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

Define skirt fold thickness (spt) method, Define Skirt Fold Thickness (S...

Define Skirt Fold Thickness (SPT) Method? Skin fold measurement is the most widely used field method of body composition assessment. The skin fold (SKF) is an indirect measu

Medical records, Medical Records This includes: health history o...

Medical Records This includes: health history of patient/client  a report of the findings on examination  signs and symptoms  observation records  progress

What do you mean by osteichthyes and condrichthyes, Q. From which features ...

Q. From which features do osteichthyes and condrichthyes get these names? "Chondros" means cartilage, "ictis" means fish (both from the Greek) the name chondrichtians is for fi

Briefly discuss the salmonella food infection, Briefly discuss the Salmonel...

Briefly discuss the Salmonella food infection. • Salmonella food infection is caused by Salmonella gastroenteritis. Transmitted by faecal contamination of foods. In

Why to dilute this stock to give the desired concentration, You are working...

You are working on a protocol in lab that requires 10ml of a 5% saline solution for a particular step. All you have in your lab is a 20% saline stock solution. How can you dilute t

History of ecology, History of Ecology The roots of ecology lie in Natu...

History of Ecology The roots of ecology lie in Natural History, which is as old as human civilisation itself. As a matter of fact man indulged in ecology in a practical sort of

Mechanism of regulation, A number of protein-coding genes are active in all...

A number of protein-coding genes are active in all cells and are required for so- called house-keeping functions such as the enzymes of glycolysis, the citric acid cycle and the pr

Ecosystem as a unit of nature , Ecosystem as a Unit of Nature An ...

Ecosystem as a Unit of Nature An ecosystem can be visualised as a functional unit of nature representing complex interactions between living and non-living components. Th

Causes of solid wastes, The main causes for the rapid growth in the quantit...

The main causes for the rapid growth in the quantity of solid wastes are- (i)     Over population: the ever increasing population is increasing all types of pollution; same is t

What is surgical therapy, Surgical Therapy The clinician may use a surg...

Surgical Therapy The clinician may use a surgical approach when non-surgical therapies are not indicated or are unsuccessful. The surgical techniques are modified from those

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd