Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

How different are the actions of antibodies against bacteria, How different...

How different are the actions of antibodies against bacteria and against virus? Why is the cellular immune response activated in case of chronic viral infection? The antibodies

Future directions in biodiversity valuation, The methods that can be used f...

The methods that can be used for valuing biodiversity are still evolving at the global level, but studies have been done on how biodiversity values can be incorporated into the pro

Indications for coronary artery bypass surgery, Indications for Coronary Ar...

Indications for Coronary Artery Bypass Surgery :  The modalities of treatment for coronary artery disease iuc: (1) medical, (2) angioplasty and stenting, and (3) coronary arte

Standard mrna and fibroblasts, You have discovered a novel alternatively sp...

You have discovered a novel alternatively spliced gene (gene X) and you wish to study its regulation in an in vitro splicing assay.  The alternatively spliced product retains intro

Gaseous fuels and advantages and disadvantages, Gaseous fuels are increasin...

Gaseous fuels are increasingly used in industrial as well as domestic uses. Gaseous fuels have very high calorific value and comparatively higher thermal efficiency than solid and

Popularity of chromatography - basic separation technique, Define Popularit...

Define Popularity of Chromatography - Basic Separation Technique? Chromatography is popular because: (a) minute quantities can be analysed qualitatively and quantitatively,

Signify the glands which are located at upper end of kidney, Part of the en...

Part of the endocrine system in humans, these 2 glands are small bodies located at upper end of every kidney. While these glands perform a range of functions, two of the most signi

What is contact osteogenesis, Contact Osteogenesis In this the osteoge...

Contact Osteogenesis In this the osteogenic cells attach to the implant surface and the new (de novo) bone is formed on the implant surface first. The developing bone matrix c

Explain micronutrient deficiencies during kwashiorkor, Explain Micronutrien...

Explain Micronutrient deficiencies during kwashiorkor? Almost all the children manifest anaemia (due to iron deficiency) of some degree. Eye signs of vitamin A' deficiency are

Define strategies for to overcome from alzheimer''s disease, Define Strateg...

Define Strategies for to overcome from alzheimer's disease? Some of these, based on the stage of the disease and individual needs are: a. supervising meal times with minimal

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd