Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

How is the blood typing concerning the abo system, How is the blood typing ...

How is the blood typing concerning the ABO system and the Rh usually done? In the blood typing for the ABO system and the Rh system a blood sample is collected from the person

Define energy expenditure in hot environments, Define Energy Expenditure in...

Define Energy Expenditure in Hot Environments? Energy expenditure in hot environments is increased by a small but significant amount because of additional work of ventilation a

What were genotypes of the f2 plants crosses, A snapdragon plant that bred ...

A snapdragon plant that bred true for white petals was crossed to a plant that bred for purple petals, and all the F1 had white petals. The F1 was selfed. Among the F2, three other

Explain brachial or radial approach, Q. Explain Brachial or Radial Approach...

Q. Explain Brachial or Radial Approach ? This technique involves performing the coronary angiogram through the right brachial artery in the right ante-cubital fossa. Usually a

Transpiration, Most of the water taken up by a plant passes through it and ...

Most of the water taken up by a plant passes through it and is evaporated to the atmosphere.What use is made of the tiny fraction of this water which is retained by the plant?

Define iodothyronine deiodinases - functions of selenium, Define Iodothyron...

Define Iodothyronine Deiodinases - functions of selenium in humans? Another group of selenoproteins are the iodothyronine deiodinases essential for the conversion of thyroxine

Kingdoms, The organisms that live in hostile environments that cannot suppo...

The organisms that live in hostile environments that cannot support other forms of life are members of what kingdom?

What is the enzyme reverse transcriptase present in hiv, Q. Which type of v...

Q. Which type of virus is the HIV? What is the enzyme reverse transcriptase present in HIV? HIV is a retrovirus that is RNA viral (its genetic material is RNA and not DNA).

Zoology, Protozoa general characters and classification

Protozoa general characters and classification

What volume of water to make solution, You need to prepare 500 ml of a solu...

You need to prepare 500 ml of a solution containing 10 mM Tris, 0.15 M NaCl and 1 mg/ml SDS. At your work disposal are stock solutions containing 1 M Tris, 2.5M NaCl and 10% (w/v)

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd