Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

Blunt or non-penetrating injury, Blunt or Non-penetrating Injury When ...

Blunt or Non-penetrating Injury When body is struck by a blunt object such as steering wheel or blows to chest with blunt object. External injury may appear minor but the

What is difference between the beta and the alpha-protien, Q. What is the d...

Q. What is the difference between the beta-sheet and the alpha-helix protein conformations? Beta-sheet and Alpha-helix conformations are the two main types of secondary structu

Explain iron and zinc, Give information as asked about the following minera...

Give information as asked about the following mineral nutrients in plants: a. Iron: i. it is a constituent of-, ii. it's one typical deficiency symptom. b. Zinc:

Indication in circulatory assist devices, Indication :  IABP is commonly u...

Indication :  IABP is commonly used to supporting failing left ventricle after open-I1ca1-t surgery or in cardiogenic shock after myocardial infarction. It is at times used in uns

Describe the uses-process and outcome of pgd, 1.  Identify and compare the ...

1.  Identify and compare the methods of somatic gene therapies for ADA deficiency described on pp. 404-405 (Lewis) and OTC deficiency described on pp. 405-406 (Lewis). 2.  Compa

Explain etiology and clinical feature of parkinson''s disease, Explain the ...

Explain the Etiology and Clinical Features of Parkinson's disease? The cause of Parkinson's is unknown. Genetic predisposition (in most cases the reason for the death of these

Define neural and neurotransmitter control, Q. Define Neural and Neurotrans...

Q. Define Neural and Neurotransmitter Control? Coronary arteries are richly innervated by adrenergic and parasympathetic nerves. Both alpha 1 and alpha 2 adrenergic receptors a

Pulmonary valvotomy cardio bypass and use cardioplegia, Pulmonary Valvo...

Pulmonary Valvotomy on Cardio Pulmonary Bypass and use of Cardioplegia :  Single aortic cannulation and separate SVC and IVC cannulation arc done. The cavae are snared to

Determine recommended nutrient intakes by selenium, Determine recommended n...

Determine recommended nutrient intakes by selenium? The FAO/WHO 2004 recommendation for nutrient intake for selenium by groups is given in Table. How do these recommendations c

Osmosis: Hypertonic Solution, If a cell were placed in a hypertonic solutio...

If a cell were placed in a hypertonic solution what could it do to protect itself?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd