Explain rifabutin, Biology

Assignment Help:

Explain Rifabutin

Two alternative regimens are based on the fact that rifabutin appears to be as effective as rifampin against TB, and has less effect on protease inhibitor levels. The first substitutes low-dose rifabutin (150 mg once/day or 300 mg 3x/week) for rifampin in the standard regimen (i.e., isoniazid, rifabutin, pyrazinamide and ethambutol) and uses higher than usual doses of indinavir (Crixivan) or nelfinavir (Viracept), or standard doses of amprenavir (Agenerase) or fos amprenavir (Lexiva)  as the protease inhibitor.

The second decreases the rifabutin dose further to 150 mg every other day or 3 times weekly and gives it with standard doses of atazanavir  (Reyataz), ritonavir/lopinavir (Kaletra) or ritonavir alone or combined with other protease inhibitors. Saquinavir (Fortovase, Invirase) alone should not be used. If the HAART regimen contains nevirapine, the usual dose of rifabutin should be used. Higher rifabutin doses (450-600 mg daily) are needed if the HAART regimen contains efavirenz.

 


Related Discussions:- Explain rifabutin

What do you mean by neurotransmitters, Q. What do you mean by neurotransmit...

Q. What do you mean by neurotransmitters? - Nicotinic receptors (nicotine mimics the effects of Ach here). Found at NM-junction, ANS ganglions in general. Binding of Ach to

Private or voluntary health insurance schemes, Normal 0 false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Important Value Index (IVI) calculation, How can we calculate the IVI from ...

How can we calculate the IVI from a total number of (30) quadrats (each 30 x 30 m quadrats)

Disbeliefs about insulin injection, Some people have disbeliefs regarding i...

Some people have disbeliefs regarding insulin injection. You have to find out if there are any disbeliefs and try to explain the importance of insulin injection. Do not force the p

Explain about insulin concentrations, Insulin Concentrations The doctor...

Insulin Concentrations The doctor always prescribes insulin dosage in units. Thus all types of insulin (crystalline, NPH, Lente, and so forth) is available in 10-ml vials that

Explain the photosensitive detectors, Explain the Photosensitive Detectors?...

Explain the Photosensitive Detectors? A wide range of detectors varying in senstivity and cost are available. They contain a light sensitive surface that releases electrons in

What is the action mechanism of the antiretroviral drugs, What is the actio...

What is the action mechanism of the antiretroviral drugs called protease inhibitors which are used against HIV infection? Protease inhibitors are some of the antiretroviral dru

Do echinoderms have circulatory and respiratory systems, Q. Do echinoderms ...

Q. Do echinoderms have circulatory and respiratory systems? In echinoderms there are not well- defined respiratory with the exception of the holothurian group and circulatory s

What are spontaneous mutations, 1. DNA damaga can be spontaneous or can be ...

1. DNA damaga can be spontaneous or can be 'Induced by external agents a. What are 'spontaneous' mutations? Give examples of causes of spontaneous mutations and the kinds od DNA

Determine the categories of sleep disorders, Determine the categories of sl...

Determine the categories of sleep disorders Sleep disorders are generally divided into two major groups: 1) Narcolepsy, which is characterised by excessive sleep or brief in

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd