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Resistance to Isoniazid
The most common pattern of resistance is isolated resistance to isoniazid, which can be treated with rifampin, pyrazinamide and ethambutol for 6-9 months. A quinolone is often added if there is extensive disease; streptomycin is an alternative to ethambutol. Patients who cannot tolerate pyrazinamide can take rifampin and ethambutol for 12 months.
Outline the importance of buffer systems in the human body. In addition, describe the main biological buffer systems and how they function.
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