Explain major histocornpatability complex (mhc), Science

Assignment Help:

Explain Major Histocornpatability Complex (MHC)

Major histocompatability complex is also known as the Human Leukocyte Antigen (HLA). MHC molecules are important components of the immune response. They permit cells that have been invaded by an infectious organism to be detected by the cells of the immune system called T-lymphocytes or T-cells. The MHC molecules do this by offering fragments of proteins (peptides) belonging to the invader on the surface of the cell. The T-cell recognizes the foreign peptide attached to the MHC molecule and binds to it, an action which stimulates the T-cell to either destroy or cure the infected cell. The MHC, therefore, is a set of genes that code for cell surface glycoproteins. These glycoproteins mark the body cells as 'self' and are divided into two main classes - class I MHC molecules are found on the surface of almost every cell of the body.

Class ll MHC molecules are confined to a few specialized cell types, such as macrophages, B-cells and activated T-cells. Each MHC antigen combination forms a unique complex that is recognized by specific antigen receptors on T-cells as 'self'. T-cell surface proteins CD4 and CD8 greatly enhance the interaction between an antigen presenting cell (APC) and killer T-cell and between AF'C and helper T-cell, respectively. The primary immunological function of MHC molecules, therefore, is to bind and "present" antigenic peptides on the surfaces of cells for recognition (binding) by the antigen- specific T-cell receptors (TCRs) of lymphocytes. The other specific defence mechanism in our body is the antibodies. Let us learn about their role in the immune system and their interaction with antigens.


Related Discussions:- Explain major histocornpatability complex (mhc)

Feeding in animals, feeding modes of insect,reptiles,amphipians,bird,fish a...

feeding modes of insect,reptiles,amphipians,bird,fish and mammals

What is clay minerals, What is clay minerals The fraction of secondary ...

What is clay minerals The fraction of secondary minerals is often mixed with primary minerals and oxides of iron, aluminium and silicon and has a size of less than       0.002

Types of energy, give examples for one energy transformed to another energy...

give examples for one energy transformed to another energy

DESALINATION FOR FUTURE WATER SUPPLY, SEA WATER HAS TO BE FILTERED TO REMOV...

SEA WATER HAS TO BE FILTERED TO REMOVE MOST SOLID IMPURITIES IN IT BEFORE IT UNDERGOES MEMBRANE DESALINATION .SUGGEST ONE REASON.

Gravity, Why does gravity effect people?

Why does gravity effect people?

Venus-the clouded planet, Venus-the Clouded Planet Venus, our nearest p...

Venus-the Clouded Planet Venus, our nearest planetary neighbour, only 40 million km away, has its surface hidden from view by a dense yellowish-white cloud, which extends to 80

Differentiate between soil water content and plant soil, Differentiate betw...

Differentiate between soil water content and plant available soil moisture.  The mass of water lost relative to mass of dry soil is called soil water content whereas plant avai

Stomach, Describe the structure of the stomach. How is it modified to carry...

Describe the structure of the stomach. How is it modified to carry out its functions? How does It compare to that of the fetal pig?

Atmospheric pressure with a rubber sucker, Measuring atmospheric pressure w...

Measuring atmospheric pressure with a rubber sucker The force needed to pull the sucker away from a smooth surface can be found by using a spring balance. The area on which the

Enzymes of intestinal juice, Enzymes of intestinal  juice Aminopepetid...

Enzymes of intestinal  juice Aminopepetidase is an  exopeptidase and cleaves peptide bonds next  to N-terminal amino acids of polypeptides and oligopeptides (unlike carboxypept

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd