Explain major histocornpatability complex (mhc), Science

Assignment Help:

Explain Major Histocornpatability Complex (MHC)

Major histocompatability complex is also known as the Human Leukocyte Antigen (HLA). MHC molecules are important components of the immune response. They permit cells that have been invaded by an infectious organism to be detected by the cells of the immune system called T-lymphocytes or T-cells. The MHC molecules do this by offering fragments of proteins (peptides) belonging to the invader on the surface of the cell. The T-cell recognizes the foreign peptide attached to the MHC molecule and binds to it, an action which stimulates the T-cell to either destroy or cure the infected cell. The MHC, therefore, is a set of genes that code for cell surface glycoproteins. These glycoproteins mark the body cells as 'self' and are divided into two main classes - class I MHC molecules are found on the surface of almost every cell of the body.

Class ll MHC molecules are confined to a few specialized cell types, such as macrophages, B-cells and activated T-cells. Each MHC antigen combination forms a unique complex that is recognized by specific antigen receptors on T-cells as 'self'. T-cell surface proteins CD4 and CD8 greatly enhance the interaction between an antigen presenting cell (APC) and killer T-cell and between AF'C and helper T-cell, respectively. The primary immunological function of MHC molecules, therefore, is to bind and "present" antigenic peptides on the surfaces of cells for recognition (binding) by the antigen- specific T-cell receptors (TCRs) of lymphocytes. The other specific defence mechanism in our body is the antibodies. Let us learn about their role in the immune system and their interaction with antigens.


Related Discussions:- Explain major histocornpatability complex (mhc)

Resource maps, Types of Resource Maps: Generally,  several  types of ...

Types of Resource Maps: Generally,  several  types of maps, based on the type of.resburces,  are prepared. Some of these are: Soil Maps showing the types of  soil, their comp

PHYSICAL ENVIRONMENT, WHY THE SUN IS CONSIDERED AS A COMPONENT OF THE PHYSI...

WHY THE SUN IS CONSIDERED AS A COMPONENT OF THE PHYSICAL ENVIRONMENT

Milky way galaxy, The Milky Way Galaxy: The white band  stretched ac...

The Milky Way Galaxy: The white band  stretched across the night  sky  is, in  fact, a partial view of  the Milky Way Galaxy. Being inside  the Galaxy, we can see it only in

Explain the law of diminishing return, Explain the law of diminishing retur...

Explain the law of diminishing return. The increase in the yield by a unit increase of the deficient factor is proportional to the decrease from maximum.

Shannons theorem, We know from Shannon's Theorem, Maximum data rate of a ch...

We know from Shannon's Theorem, Maximum data rate of a channel in bps (B) = Hlog2 ( 1+S/N ) _ 1 Where H = bandwidth in Hz S/N = signal-to-noise ratio We also know that Db = 10log10

Bdp, describe the factors which decide the broad area of scientific activit...

describe the factors which decide the broad area of scientific activity?

Define the functions of platelets, Define the functions of platelets Th...

Define the functions of platelets The main function of platelets, or thrombocytes, is to stop the loss of blood from wounds, i.e. haemostasis. Let us learn about this function.

What is topography, What is Topography The location of a soil on a land...

What is Topography The location of a soil on a landscape i.e., topography or relief of the land is an important passive factor in soil formation as it can affect the impact of

Explain nerve supply of the gastrointestinal tract, Explain Nerve Supply of...

Explain Nerve Supply of the Gastrointestinal Tract The gastrointestinal tract is supplied by nerves from both sympathetic and parasympathetic nervous system. The parasympatheti

What are the factors affecting soil formation, What are the Factors Affecti...

What are the Factors Affecting Soil Formation  Parent materials formed due to weathering of rocks are transported from the place of their origin and re-deposited before they ar

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd