Explain major histocornpatability complex (mhc), Science

Assignment Help:

Explain Major Histocornpatability Complex (MHC)

Major histocompatability complex is also known as the Human Leukocyte Antigen (HLA). MHC molecules are important components of the immune response. They permit cells that have been invaded by an infectious organism to be detected by the cells of the immune system called T-lymphocytes or T-cells. The MHC molecules do this by offering fragments of proteins (peptides) belonging to the invader on the surface of the cell. The T-cell recognizes the foreign peptide attached to the MHC molecule and binds to it, an action which stimulates the T-cell to either destroy or cure the infected cell. The MHC, therefore, is a set of genes that code for cell surface glycoproteins. These glycoproteins mark the body cells as 'self' and are divided into two main classes - class I MHC molecules are found on the surface of almost every cell of the body.

Class ll MHC molecules are confined to a few specialized cell types, such as macrophages, B-cells and activated T-cells. Each MHC antigen combination forms a unique complex that is recognized by specific antigen receptors on T-cells as 'self'. T-cell surface proteins CD4 and CD8 greatly enhance the interaction between an antigen presenting cell (APC) and killer T-cell and between AF'C and helper T-cell, respectively. The primary immunological function of MHC molecules, therefore, is to bind and "present" antigenic peptides on the surfaces of cells for recognition (binding) by the antigen- specific T-cell receptors (TCRs) of lymphocytes. The other specific defence mechanism in our body is the antibodies. Let us learn about their role in the immune system and their interaction with antigens.


Related Discussions:- Explain major histocornpatability complex (mhc)

Power, Calculate the power of a light bulb that uses 36J of electrical ener...

Calculate the power of a light bulb that uses 36J of electrical energy in 6 seconds.

Explain the basic principles of food processing, Normal 0 false...

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4

The carbon cycle, Carbon dioxide has been surmised as an significant compon...

Carbon dioxide has been surmised as an significant component in ceasing the last Ice Age, but its precise function has always been indecipherable as rising temperatures pondered in

Mode of Nutrition, Ask question #Minimum 1000 words accepted#

Ask question #Minimum 1000 words accepted#

Objectives of hazards in biology laboratory, Objectives After studying ...

Objectives After studying this unit you should be able to: 1.  state the principal hazards of biology lab work, 2.  describe the ways to minimize these dangers, 3.  ex

Mineral has the name "bloodstone", This mineral has the name "bloodstone" b...

This mineral has the name "bloodstone" because it provides a deep red color on a streak test. What is its chemical formula? Fe 2 O 3

Define health insurance, Question 1 What are the different types of budget...

Question 1 What are the different types of budgets? Explain the budgeting process for healthcare services Question 2 Explain the concept of demand and supply in healthcare

Maintain the calcium levels of body– function of kidney, Maintain the Calci...

Maintain the Calcium Levels of Body– Function of Kidney Maintain the body’s calcium levels. Along with parathormone and calcitriol, kidney helps the body to absorb calcium.

Science, factors which decide the broad area of scientic activity

factors which decide the broad area of scientic activity

Nuclear fission, Nuclear Fission: Splitting the Atom  You know  that ...

Nuclear Fission: Splitting the Atom  You know  that atoms are made up of a nucleus and electrons moving around the nucleus, and the nucleus  is made up of protons and neutron

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd