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Fischer 's template or lock and key model
According to this model, the catalytic site of the enzyme has a proper conformation compatible to a specific substrate even in the absence of the substrate molecule. The catalytic site binds the substrate and catalyzes the reaction without any change in its own three dimensional conformation. It has become possible to explain the specificity of many enzymes for only one of the stereoisomers of the substrate by this model.
Write in 3-4 lines about foot examination Foot ulceration and amputation are common and major causes of morbidity and disability in people with diabetes. Skin integrity should
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