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Fischer 's template or lock and key model
According to this model, the catalytic site of the enzyme has a proper conformation compatible to a specific substrate even in the absence of the substrate molecule. The catalytic site binds the substrate and catalyzes the reaction without any change in its own three dimensional conformation. It has become possible to explain the specificity of many enzymes for only one of the stereoisomers of the substrate by this model.
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Cost due to Damage to Equipment Cost due to Damage to Equipment, Property etc. Tooling may have to be redesigned, adding cost. Cost due to reduced output and delay
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