Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Define classification of carbohydrates - monosaccharide, Define Classificat...

Define Classification of Carbohydrates - Monosaccharide? Monosaccharides or simple sugars are those carbohydrates that cannot be hydrolyzed into simpler carbohydrates. E.g. gl

Write the definition of counselling, Q. Write the definition of counselling...

Q. Write the definition of counselling? Definition of counselling "A process of helping or enabling a person / persons to solve certain interpersonal, emotional problems and

Lipids, LIPIDS Term given by Bloor. Lipids do not form polymers ...

LIPIDS Term given by Bloor. Lipids do not form polymers in nature except cutin (polymere of fatty acids). Most lipids are formed of fatty acids & alcohol. Ester bo

Explain starch, Starch It is a plant polysaccharide synthesized by  the...

Starch It is a plant polysaccharide synthesized by  the plant by photosynthesis and stored mainly  in  grains,  legumes,  roots  and  tubers.  Its molecular formula is (C 6 H 1

Explain about derived proteins, Derived Proteins These are not naturall...

Derived Proteins These are not naturally occurring proteins and are obtained from simple proteins by the action of enzymes and chemical agents, heat, mechanical shaking, UV or

Compute the osmolarity of a solution, Calculate the osmolarity of a solutio...

Calculate the osmolarity of a solution of 5% dextrose in water (dextrose = glucose, molec. Wt. = 180).

Explain trichomoniasis, Trichomoniasis  Oral metronidazole has been the...

Trichomoniasis  Oral metronidazole has been the treatment of choice for trichomoniasis. Tinidazole (Tindamax - Medical Letter 2004; 46:70), a nitroimidazole similar to metronid

What is an open circulatory system, What is an open circulatory system? ...

What is an open circulatory system? Open circulatory system is the one in which blood does not circulate only in blood vessels but it also falls in cavities that irrigate tissu

Spermatogonia - spermatozoa, Normal 0 false false false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4 Spermatogonia - Spe

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd