Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Explain the pour plate method, Explain the Pour Plate Method Isolated c...

Explain the Pour Plate Method Isolated colonies can also be obtained by pour plate method. The method involves mixing of small volume of microbial suspension with molten nutrie

Roles of fatty acid, Fatty acids have four main biological roles: 1.  Th...

Fatty acids have four main biological roles: 1.  They are used to create sphingolipids and glycerophospholipids which are necessary elements of biological membranes; 2.  Nume

Heterospermy, What is heterospermy?also give its significance?

What is heterospermy?also give its significance?

Zoonoses disease- taeniasis, Taeniasis Taeniasis is a zoonotic diseas...

Taeniasis Taeniasis is a zoonotic disease caused by specific cestodes. The two parasites of major importance are Taenia saginata and T. solium. Both in their adult forms, are

Biota of the neritic oceanic zone, Biota of the Neritic Oceanic Zone T...

Biota of the Neritic Oceanic Zone This zone constitutes 75 per cent of the total oceanic area and is relatively rich in species and high in productivity owing to factors such

Seed, Seed A seed is a mature ovule enclosing an embryonic plant, stor...

Seed A seed is a mature ovule enclosing an embryonic plant, stored food material (in endosperm, persistent nucellus or embryo itself) and a seed coat formed by one or two inte

Explain community dietitians, Explain Community dietitians Community d...

Explain Community dietitians Community dietitians or  nutritionists  may  counsel  individuals and  groups on  sound nutrition practices  to  prevent  disease, maintain  healt

Explain genotypical and phenotypical forms, In the F2 generation of hybridi...

In the F2 generation of hybridization for a given trait conditioned by a pair of alleles T and t, according to Mendel's first law what are the genotypes of each phenotypical form?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd