Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Explain the life cycle of water, Explain the life cycle of Water? The ...

Explain the life cycle of Water? The water cycle , or hydrologic cycle, is one of the most important processes to living organisms on Earth. Consider the following facts:

Common causes related with angina pectoris, Q. Common causes related with a...

Q. Common causes related with angina pectoris? • The usual cause of angina is the narrowing of the major coronary artery due to atherosclerosis. • Systemic hypertension inc

How many different genotypes can the individual present, Considering a pair...

Considering a pair of homologous chromosomes containing a gene having two different alleles how many different genotypes can the individual present? If a gene of the diploid sp

Differences and similarities between nematodes and annelids, Q. What are th...

Q. What are the morphological differences and similarities between nematodes and annelids? Nematodes, like annelids, have a cylindrical elongated body. Annelids differentiate f

Temperate deciduous forests, Going south of taiga you would reach the tempe...

Going south of taiga you would reach the temperate regions of the planet. These regions experience moderate temperatures on average that change during four distinct seasons. They h

Explain about atrial septal defect, Explain about Atrial Septal Defect (ASD...

Explain about Atrial Septal Defect (ASD) ? ASD occurs as an isolated anomaly in 5- 10 per cent of all CHDs. These communications occur in four sites i.e. in the central portion

What is gene, What is gene? Gene is a sequence of DNA nucleotides that ...

What is gene? Gene is a sequence of DNA nucleotides that codifies the production of a protein.

Explain biotin (vitamin h), Biotin (vitamin H) It was revealed  that eg...

Biotin (vitamin H) It was revealed  that egg yolk could prevent dermatitis and emaciation  in  rats that were kept on  raw  egg white a$ the main protein source. The factor of

Define hocm murmur characteristics in details, Define HOCM Murmur character...

Define HOCM Murmur characteristics in details? Characteristics: The murmur is harsh, crescendo-decrescendo audible along the left sternal border, radiates to the base of heart

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd