Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

A useful way to grow seeds, A useful way to grow seeds Tie a piece of c...

A useful way to grow seeds Tie a piece of cloth over the mouth of an old potted meat jar. Permit extra cloth to hang down the sides and dip in about 2 cm of water contained in

Explain tropical rain forests in biomes, Explain Tropical Rain Forests in b...

Explain Tropical Rain Forests in biomes? You probably are well aware of the danger that the world's rain forests are facing in terms of extinction! There are huge numbers of sp

Define shell fish as a rich source of protein, Define Shell Fish as a rich ...

Define Shell Fish as a rich source of protein? Information on shellfish is fragmentary and incomplete. In shell fish, the shell comprises of a large portion of live weight of t

Offspring, #q1. If offspring exhibit a 3:1 phenotypic ratio, what are the g...

#q1. If offspring exhibit a 3:1 phenotypic ratio, what are the genotypes of a parent?uestion..

Explain about cerebral hemispheres, How is it structurally explained that t...

How is it structurally explained that the motor activity of the left side of the body is controlled by the right cerebral hemisphere and the motor activity of the right side of the

What is complete transposition of arteries, What is complete transposition ...

What is complete transposition of arteries? Complete transposition of the great arteries (dTGA): The atria and ventricles are connected appropriately i.e., the right atrium dra

What is the thermopenetration concept, What is the thermopenetration concep...

What is the thermopenetration concept? The pasteurization of products packed in glass containers leads to a problem of a specific nature, which is referred to as 'thermopenetra

How different are pteridophytes from bryophytes, How different are pteridop...

How different are pteridophytes from bryophytes regarding substance transport? Pteridophytes are tracheophyte (vascular) plants, i.e., they have tissues specialized in conduct

Explain genetic algorithms, Your task is to describe genetic algorithms, ex...

Your task is to describe genetic algorithms, explain why genetic algorithms are useful in solving the problem you have been set and conduct an investigation into the optimum parame

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd