Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Explain prevalence in coronaw artery disease, Explain Prevalence in coronaw...

Explain Prevalence in coronaw artery disease ? The first report to highlight the high prevalence of CAD among Indian expatriates came from an autopsy study done in Singapore. C

How different are fecundation in osteichthyes, How different are fecundatio...

How different are fecundation in osteichthyes and in chondrichthyes? In chondrichthyes fecundation is internal by means of copulation. In osteichthyes fecundation generally is

Explain how the boll weevil populations changed, The boll weevil, an insect...

The boll weevil, an insect native to Mexico and Central America, is another pest of commercial cotton. When chemical insecticides were first discovered, they proved highly effectiv

Growth-form and structure, Growth-form and Structure In a community the...

Growth-form and Structure In a community the number of species and size of their populations vary greatly. A community may have one or several species. The environmental factor

Endocrine glands - gastro-intestinal mucosa, GASTRO-INTESTINA L MUCOSA - ...

GASTRO-INTESTINA L MUCOSA - It develops from the endoderm of the embryo. Inner most layer of the wall of the alimentary canal is called mucosa. Certain cells of the mucosa

How structure of the subunits changed, The holoenzyme is denatured by heat ...

The holoenzyme is denatured by heat at very high temperature. It is found that two polypeptides, although denatured, contains chains that remain together as a unit, while two other

Show the artificial keys, Q. Show the Artificial Keys? These are based ...

Q. Show the Artificial Keys? These are based on the resemblances and differences of some prominent characters in the taxa. These are based on the phylogenetic relationship b

What is cellulose, What is cellulose? Cellulose is a long-chain polymer...

What is cellulose? Cellulose is a long-chain polymeric polysaccharide carbohydrate, of beta-glucose. It creates the primary structural component of green plants. The primary ce

excreation, ARE BONY FISHES AMMONOTELIC?

ARE BONY FISHES AMMONOTELIC?!

Nutrition, type of nutrition in platypus and ant eater

type of nutrition in platypus and ant eater

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd