Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Write the meaning of dsme, Q. Write the meaning of DSME? Generally, it ...

Q. Write the meaning of DSME? Generally, it is observed that soon after being diagnosed with diabetes, the patient gets worried or get depressed. This is a stage where the pati

Volvocine Protozoa, Why is Volvocine Protozoa not considered an animal?

Why is Volvocine Protozoa not considered an animal?

Epizootic lymphangitis, Epizootic lymphangitis Epizootic lymphangitis ...

Epizootic lymphangitis Epizootic lymphangitis (pseudo-glanders) is a chronic, insidious and highly contagious fungal disease of equines particularly horse and very rarely of c

Mechanisms of sex determination and dosage compensation, XYY humans are fer...

XYY humans are fertile males. XXX humans are fertile females. What do these observations reveal about the mechanisms of sex determination and dosage compensation?

Situation in which the mistakes holds in dna replication, Q. Mistakes may h...

Q. Mistakes may happen during each copying process. The same is true for the DNA replication. Are there correction systems in cells that try to mend those mistakes? Under which sit

Nutritiona, Describe the tasks of various body systems in breaking down car...

Describe the tasks of various body systems in breaking down carbohydrates into glucose to fuel the cells work

Discuss resting membrane potential and nerve action potentia, Question 1 W...

Question 1 Which are the 3 different processes in the formation of urine? Explain Question 2 Discuss resting membrane potential and nerve action potential Question 3 Nam

Explain kingdom animalia, Kingdom Animalia Multicellular, heterotrophic, ...

Kingdom Animalia Multicellular, heterotrophic, eukaryotes, tissues are specialised and most of them have organs, mostly highly responsive. Only gametes are haploid, fertilisation

State the term - viral infections, State the term - Viral Infections A ...

State the term - Viral Infections A virus is an encapsulated aggregate of nucleic acid that may be made of either DNA or RNA. Some viruses, such as those causing poliomyelitis

Epidemiological association between hemophilia and HIV, What is the epidemi...

What is the epidemiological association between hemophilia and HIV infection? As hemophilic patients need frequent transfusions of clotting factors (VIII or IX) they are more s

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd