Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Surface Processes on Earth, Which of the following is not a type of mass mo...

Which of the following is not a type of mass movement that results from the force of gravity? A. Landslide B. Creep C. Deflation D. Mudflow

What happens within the cell in the second interface period, What are the e...

What are the events that mark the beginning and the end of the second interphase period? What happens in the cell in this period? The second interphase period is the S. It begi

Metallurgical coke, Metallurgical coke should have following characteristic...

Metallurgical coke should have following characteristics: 1.      Purity: low amounts of moisture, ash, sulphur & phosphorous should be present. 2.      Porosity: it should b

Cell culture products, Cell culture products: Animal cell cultures ar...

Cell culture products: Animal cell cultures are used to generate virus vaccines, as well as different kind  of useful biochemical which are mainly high molecular weight prote

Comparison with amphibian gastrulation, Comparison with Amphibian Gastrulat...

Comparison with Amphibian Gastrulation On comparison of chick gastrulation along with amphibian gastrulation you will find many similarities along with significant difference

Hepatitis, He p atitis Hepatitis is defined as degenerative/ inflamma...

He p atitis Hepatitis is defined as degenerative/ inflammatory processes of the liver. The clinical manifestations associated with hepatic dysfunctions results from impairmen

Is there respiratory pigment in the annelid blood, Q. Is there respiratory ...

Q. Is there respiratory pigment in the annelid blood? The blood in beings of the phylum Annelida contains the respiratory pigment hemoglobin the same found in chordates and oth

Describe the part of the female reproductive system, Q. What is the part of...

Q. What is the part of the female reproductive system where fecundation occurs? Fecundation in general occurs in the Fallopian tubes but it can also take place within the uteru

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd