Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Agro industrial-mineral supplements, Mineral supplements There are two...

Mineral supplements There are two major classes of mineral sources: inorganic and organic. Organic complexes, however, have been shown to be more effectively absorbed by the a

Etiological factor of dyspepsia, Q. Etiological factor of dyspepsia? Th...

Q. Etiological factor of dyspepsia? The main etiological factor of dyspepsia is the failure of proper digestion and absorption of food in the alimentary tract and the consequen

Disorder of skeleton and joints, DISORDER OF SKELETON AND JOINTS - 1 ...

DISORDER OF SKELETON AND JOINTS - 1 .      Sprain - It involves a stretching or tearing of tendons or ligaments. 2.      Arthritis - It is infalmation of joints.

Disability adjusted life years (dalys), Disability Adjusted Life Years (DAL...

Disability Adjusted Life Years (DALYs) DALYs is a measure for the overall ‘burden of disease’. Originally developed by the World Health Organization (WHO), it is being increas

Antimicrobial barriers - proliferation of microorganisms, Q. Antimicrobial...

Q. Antimicrobial Barriers -  proliferation of microorganisms? The first barrier is the integument: a physical barrier to protect the food, e.g., the shell on eggs, the skin on

Head examination of new born, Head - check for size, shape or fontan...

Head - check for size, shape or fontanelles, caput, or any other abnormality. Fontanel - anterior fontanel is diamond shaped having size of 2.5 - 4.5 cms. It close

Use of nitrates and nitrites in microorganisms, Q. Explain the Use of nitra...

Q. Explain the Use of nitrates and nitrites in microorganisms? The use of nitrates and nitrites has been widely used in the curing of meat. The reduction of nitrates by bacteri

Define the concept of nutrition, Define the Concept of Nutrition? Nutri...

Define the Concept of Nutrition? Nutrition may be defined as the science of food and its relationship to health. It is concerned primarily with the past played by nutrients in

Photosynthesis, why we add some sodium bicarbonate in water?

why we add some sodium bicarbonate in water?

Define characteristic of doppler echocardiographic, Q. Define characteristi...

Q. Define characteristic of Doppler Echocardiographic? Ans. Doppler findings of cardiac tarnponade are based on the following characteristic respiratory variations in intr

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd