Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Differences between genomes in prokaryotes and eukaryotes, What are the dif...

What are the differences between genomes in prokaryotes vs. eukaryotes?

What are cell kind that form the xylem, What are cell kind that form the xy...

What are cell kind that form the xylem? What are the major features of those cells? The major cells of the xylem are the tracheids and the vessel elements (these only in angios

State the principles of behaviour change communication, Principles of behav...

Principles of behaviour change communication - BCC should be integrated with program goals from the starting. BCC is a necessary part of diabetes prevention, care and support p

What is qt dispersion, Q. What is QT Dispersion? Is the difference betw...

Q. What is QT Dispersion? Is the difference between the QT interval measured from one part of the heart and the QT interval measured from another part of the heart. The QT inte

Explain bidirectional glenn shunt under cardiopulmonary, Explain Bidirectio...

Explain Bidirectional Glenn Shunt under cardiopulmonary Bypass ? The ascending aorta and SVC at innominate jugular vein junction and IVC are cannulated and child connected to c

What is the destination of the branchial clefts in humans, What is the dest...

What is the destination of the branchial clefts in humans? In humans the branchial clefts situated in the anterior region of the pharynx (also called as pharyngeal clefts) are

Explain about cmc information about drug substance, Question 1: Describ...

Question 1: Describe upon CMC information about drug substance to be submitted to IND for Phase 3 studies. Definition of CMC Explain about CMC information about drug subs

Tolerance range, Maximum and minimum range of an animal with the factors of...

Maximum and minimum range of an animal with the factors of Ph Salinity Pressure Relative human

Respiration, what chemical is normally used to test for the presence of car...

what chemical is normally used to test for the presence of carbon dioxide

Explain autosomal recessive disease, The frequency of an autosomal recessiv...

The frequency of an autosomal recessive disease in a population is 1 in a million. An unaffected person who had a sibling affected with this disease marries a lady from the pop

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd