Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Antibodies, Antibodies Antibodies are important.tools for detecting and...

Antibodies Antibodies are important.tools for detecting and localising specific molecules in the cells due to their high specificity. The first requirement for this is to produ

Metazoa, explain hadzi''s theory with reference to metazoa

explain hadzi''s theory with reference to metazoa

Conduction of impulse, CONDUCTIO N OF IMPULSE - IN NON-MYELINATED AXO...

CONDUCTIO N OF IMPULSE - IN NON-MYELINATED AXONS - The impulse moves along the axon as local effect by altering the permeability of neighbouring Na +  channels and af

Explain insect resistant crops in evolutionary way, Explain Insect resistan...

Explain Insect resistant crops in Evolutionary way Insects are a natural selection pressure so plants resistant to certain insects could have an evolutionary advantage (in

Skeleton, why do we get severe leg pains when the internal bone is cracked?...

why do we get severe leg pains when the internal bone is cracked?

Determine requirements of vitamins at high altitude, Determine requirements...

Determine requirements of Vitamins at high altitude? It is observed that requirement of vitamins is not different as compared to plains. In humans, exposure to high altitude ha

What are the homologous chromosomes, Q. What are the homologous chromosomes...

Q. What are the homologous chromosomes? Which are the human cells that do not have homologous chromosomes? Chromosomes contain genes genetic information in the form of nucleoti

Summary of health dimensions of development, Normal 0 false f...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Solar energy, It is an inexhaustible and population free source of energy. ...

It is an inexhaustible and population free source of energy. This energy maintains temperature of the earth. It causes current in the atmosphere and in ocean. The total solar energ

What is herbicide tolerant crops in evolutionary, Evolutionary ...

Evolutionary Herbicide tolerant crops (HTC) Increased use of herbicide can result in increase in development of weed resistance to that herbicide either through

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd