Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Evaluation of heart failure, The initial evaluation of new onset heart fail...

The initial evaluation of new onset heart failure should include an electrocardiogram, chest radiograph, and B-type natriuretic peptide assay. The cardiac rhythm may be normal sinu

Pelagic zone - organisation of the marine ecosystem, Pelagic Zone - Organis...

Pelagic Zone - Organisation of the Marine Ecosystem The waters contained in the sea basin, constitute the pelagic zone which is divided into The neritic zone situ

What are nymph and imago, What are nymph and imago? Nymphs are larvae o...

What are nymph and imago? Nymphs are larvae of hemimetabolic insects (like grasshoppers). They are very same to the adult insect although smaller. In holometabolic insects (lik

Functions of ecosystem, Ecosystems main functions are physical, chemical an...

Ecosystems main functions are physical, chemical and biological processes. Which is required for if maintenance of ecosystem. Some important function- 1.        Production of bi

Clothes , Clothes : The concept of clothes might have started even befo...

Clothes : The concept of clothes might have started even before weaving, as an extension of  the practice of carrying food hd  implements about.  Attachments with a convenient

How the brain influences or controls immune system, How the brain influence...

How the brain influences or controls immune system Scientists are still working to determine to what degree, and how, the brain influences or controls immune system functions,

Does glycolysis occur within the mitochondria, Does glycolysis occur within...

Does glycolysis occur within the mitochondria? Glycolysis occurs in the cytosol and not within the mitochondria. Pyruvic acid molecules later enter mitochondria to participate

What is schistosomiasis. explain in brief., What is Schistosomiasis? Explai...

What is Schistosomiasis? Explain in brief. A disease cause by the trematode parasite Schistosoma found around the world. Numerous species are responsible for diseases ranging f

Lower calorific value (lcv) or net calorific value (ncv), It is defined as ...

It is defined as the amount of heat liberated when one unit mass of fuel is burnt and the products of combustion are allowed to escape.                                  LCV = HC

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd