Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Admission of mentally patient, Admission of Mentally Patient: Volunt...

Admission of Mentally Patient: Voluntary Basis  (Voluntary Admission)   Any adult person who considers himself  to be mentally ill, can  request  the Medical Officer for

Ordinary share capital, Ordinary share capital This type of Equity fi...

Ordinary share capital This type of Equity finance is raised from the public from the sale of ordinary shares to the shareholders. This finance is presented to limited compan

Why is vision important for life on earth, Q. What is vision? Why is vision...

Q. What is vision? Why is vision important for life on earth? Vision is the ability of some living beings to distinguish, to perceive and to interpret luminous stimuli. Visi

Skin, physiology of skin

physiology of skin

Tagmatization, sample assignment on tagmatizatio

sample assignment on tagmatizatio

Explain nature of fatty acids present in the triglyceride, Explain the Natu...

Explain the Nature of fatty acids present in the triglyceride? Nature of fatty acids present in the triglyceride determines the physico-chemical properties and biological signi

How is gas exchange done in flatworms, Q. How is gas exchange done in flatw...

Q. How is gas exchange done in flatworms? Platyhelminthes exchange gases exclusively by diffusion through their body surface. This is only possible because all cells are locali

Explain identification of cancer cells from normal cells, Explain Identific...

Explain Identification of Cancer Cells from Normal Cells? Cancer cells can be distinguished from normal cells by examining them under a microscope. In a specific tissue cancer

To show the respiration of a plant, To show the respiration of a plant ...

To show the respiration of a plant Place the plant in a test tube held in a weighted wooden block. Put this in a bowl having lime water and cover the plant with a jar. Keep the

Measurement of light intensity, Measurement of Light Intensity How do w...

Measurement of Light Intensity How do we measure the intensity of a source of light falling on a surface? You know that light spreads out uniformly in all directions from a sou

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd