Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

The smooth er and rough er are similar functions, What functions of the smo...

What functions of the smooth ER and rough ER are similar?

Tools and techniques - effects of plant growth regulators, Tools and Techni...

Tools and Techniques - Effects of Plant Growth Regulators We have discussed about the "effect of auxins". In this section we shall discuss the methodology being followed in h

What are immunoglobulins, What are immunoglobulins? Immunoglobulin is t...

What are immunoglobulins? Immunoglobulin is the exchange name given to antibody. Immunoglobulins are complex proteins having an invariable portion and a variable portion and ma

What is palliative outflow patch, What is Palliative Outflow Patch ? Br...

What is Palliative Outflow Patch ? Brock described closed pulmonary valvotomy and infundibular resection using a punch on a beating heart. When both pulmonary arteries are not

Salivary analyse works on foods, Explain how salivary amylase works on food...

Explain how salivary amylase works on foods like crackers

Benefits of hand washing, Benefits of Hand washing You wash hands as a ...

Benefits of Hand washing You wash hands as a routine in daily life before cooking and eating food, after using wash room/toilet, before touching and caring a new born baby, aft

Explain the aseptic technique - sub culturing, Explain the Aseptic Techniqu...

Explain the Aseptic Technique - Sub Culturing? Aseptic technique is a series of procedures used to prevent contamination of cultures and sterile culture media. It is one of the

Population density - biological stress, Population Density - Biological Str...

Population Density - Biological Stress You are aware of what might follow an uncontrolled growth of human population. There will be competition for common consumables and for

Difference between parental gametes and recombinant gametes, In genetic rec...

In genetic recombination by crossing over what is the difference between parental gametes and recombinant gametes? The Parental gametes are those gametes that maintain the orig

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd