Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Drugs for hepatitis b, Drugs for hepatitis B Chronic HBV infection is ...

Drugs for hepatitis B Chronic HBV infection is currently treated with interferon alfa, lamivudine or adefovir. Lamivudine is much better tolerated than interferon and much les

Explain autoxidation, Autoxidation It is generally agreed that "autoxid...

Autoxidation It is generally agreed that "autoxidation", that is, the reaction with molecular oxygen via a self - catalytic mechanism, is the main reaction involved  in oxidati

LIFE PROCESSES, WHAT IS HEART? AND WHAT THEY DO WORK IN OUR BODY.

WHAT IS HEART? AND WHAT THEY DO WORK IN OUR BODY.

Green leaves give off oxygen in sunlight, Green leaves give off oxygen in s...

Green leaves give off oxygen in sunlight Place some water weed under a funnel in a beaker of water reverse a test tube full of water over the tube of the funnel. Leave the appa

Common endocrine disorders, COMMON ENDOCRINE DISORDERS: We  shall  foc...

COMMON ENDOCRINE DISORDERS: We  shall  focus on  two conditions Diabetes mellitus and Diabetes inspidus.  Diabetes Mellitus  Diabetes mellitus (DM) is a disorder of gl

Heart in amphibians, Amphibia n - 3 chambered heart 2 auricles and ...

Amphibia n - 3 chambered heart 2 auricles and 1 ventricle. Sinus venosus and truncus arteriosus (its main part is pylengium) present. Incomplete double circulation prese

Explain 1st type of hypersensitivity, It is IgE mediated hypersensitivity. ...

It is IgE mediated hypersensitivity. Typical manifestations contain asthma, food allergies, eczema, hay fever etc.

Smack, SMAC K - It is a crud by product of heroin synthesis, commo...

SMAC K - It is a crud by product of heroin synthesis, commonly called brown sugar (Poor man's heroin). The addicts heat the smack powder & inhale its vapour. It is

What is implant success, Implant success 1) An individual, unattached i...

Implant success 1) An individual, unattached implant is immobile when tested clinically. 2) A radiograph that does not demonstrate any evidence of perimplant radiolucency.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd