Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Acyanotic congenital heart disease, Acyanotic Congenital Heart Disease   ...

Acyanotic Congenital Heart Disease   In this infant has no cyanosis because there is no abnormal communication between pulmonary and systemic circulation or there  is no mixing

Describe technique operation prosthetic valve endocarditis, Describe the Te...

Describe the Technique of Operation in prosthetic valve endocarditis? The operative principle is drainage of abscess, removal of debris and valve rep or replacement to reverse

Define the basic concepts behind the spectral techniques, Define the Basic ...

Define the Basic Concepts behind the Spectral Techniques? Energy is transmitted via electromagnetic waves that are characterized by their frequency and wavelength. The physical

Explain syndrome x as a effect of obesity, Explain Syndrome X as a Effect o...

Explain Syndrome X as a Effect of Obesity? People with intra-abdominal obesity with high waist- to- hip ratio are more prone to develop the metabolic syndrome X. This is charac

What are the major morphological features of arthropods, Q What are the maj...

Q What are the major morphological features of arthropods? Arthropods present three distinguishing features: they are metameric beings (segmented body), they present articulate

What are lichens, What are lichens? How do fungi participate in this ecolog...

What are lichens? How do fungi participate in this ecological interaction? Lichens are produced by mutualist ecological interaction among fungi and algae or among fungi and cya

Ethidium bromide, Ethidium Bromide  intercalates within structure of the nu...

Ethidium Bromide  intercalates within structure of the nucleic acids in such a manner that they fluoresce under the UV light. Ethidium bromide staining is generally used to visuali

Discuss about the luria nebraska procedure, Discuss about the Luria Nebrask...

Discuss about the Luria Nebraska procedure The Luria Nebraska procedure involves an age and education correction. It is accomplished by computation of a cutoff score for abnorm

Percentage ratio of total solids and water in honey, Q. Percentage ratio of...

Q. Percentage ratio of total Solids and Water in honey? Most genuine honeys contain 13-23 per cent of water. The total solids or moisture can be estimated by drying in a vacuu

Learning objectives of metabolic diseases, Q. Learning objectives of metabo...

Q. Learning objectives of metabolic diseases? • enumerate the etiological factors and symptoms of gout and few inborn errors of metabolism, • describe the metabolic changes

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd