Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Define water losses by intestine and lungs, Define water losses by Intestin...

Define water losses by Intestine and Lungs? Intestine : A small quantity of water (about 100-200 ml) is normally lost in faeces, but this can exceed 5 L in diarrhoeal episodes

Explain atrial switch operation, Explain Atrial Switch Operation ? The ...

Explain Atrial Switch Operation ? The hospital mortality reported varies between 0 and 15 per cent. Late survival is worse for TGA with VSD compared to simple TGA. 15 year surv

What are varices, What are varices? Why are they more common in the inferio...

What are varices? Why are they more common in the inferior limbs? Varix means abnormal enlargement of veins. Varices happen when excessive pressure against the normal blood fl

General guidelines of maintaining records of patients, General Guidelines ...

General Guidelines While working in the ward, you are always required to record. You should follow the general guidelines while recording which are as follows: All entri

In which area dietitians works, In which area Dietitians works Dietitia...

In which area Dietitians works Dietitians can work in a variety of areas, as already mentioned earlier, many of these are in the  Hospitals or in  the community  as  'Clinical

Define the surgery process for cancer patient, Define the Surgery Process f...

Define the Surgery Process for Cancer Patient? Surgery is generally conducted in the absence of metastasis i.e. when a tumor is localized. Nutrition support would vary dependin

Measurement of solar energy input-radiation instruments, Measurement of sol...

Measurement of solar energy input A variety of instruments have been designed to measure the energy of solar radiations of all wavelengths as well as of a particular range of w

Explain dental care delivery system, Explain Dental Care Delivery System ...

Explain Dental Care Delivery System In the dental care delivery system: there are: patients, insurance payers and dentists For patients: Success = function + esthetics

Explain the decolourizing agent - ziehl-neelsen method, Explain the Decolou...

Explain the Decolourizing Agent - Ziehl-Neelsen Method? Acid alcohol - a mixture of 95% ethanol and 3% HCI - is used for decolourization. Before decolourization, smear is allow

Natural vegetative propagation, in natural vegetative propagation which st...

in natural vegetative propagation which structure gives rise to new individuals?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd