Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

How are mammals characterized, Q. Mammal identity card. How are mammals cha...

Q. Mammal identity card. How are mammals characterized according to examples of representing beings, skin, respiration, nitrogen waste, basic morphology, circulation, thermal contr

The process of evolutionary cephalization be described, Using examples of i...

Using examples of invertebrate nervous systems how can the process of evolutionary cephalization be described? Considering the instance of invertebrates it is observed that ev

Explain of functional property browning and anchor, Explain of Functional p...

Explain of Functional property Browning/Flavour/ Aroma Mode of action  Proteins contribute to browning by reacting with lactose and other reducing sugars present in a form

Viruses, Viruses Viruses are sub cellular, ultramicroscopic infectious...

Viruses Viruses are sub cellular, ultramicroscopic infectious agents of 20 nm-300 nm size range Many of them cause diseases like polio, dengue, small pox, measles, rabies, com

Sources of water pollution, Sources of Water Pollution There are natu...

Sources of Water Pollution There are natural sources of water pollutants such as mineral ores from rocks, chemicals, from mines and gases from atmosphere. But we will conside

Define commodity topics of food science, Define Commodity Topics of Food Sc...

Define Commodity Topics of Food Science? All issues of food science and technology of certain commodity groups, including milk and milk products (fluid milk and derivatives, ic

Health benefits of dietary factors - antinutritional effect, Define Health ...

Define Health Benefits of Other Dietary Factors with Antinutritional Effects? Despite the predominantly nutritional antagonistic effects of the factors described above, there i

What is the pineal gland, What is the pineal gland? The pineal gland, a...

What is the pineal gland? The pineal gland, also called as pineal body or epiphysis, is situated centrally in the head. It secretes the hormone melatonin, a hormone formed at n

Determine the most probable mode of inheritance, In the following pedigrees...

In the following pedigrees, the disorders or traits presented follow simple patterns of Mendelian inheritance. For each trait, determine the most probable mode of inheritance, stat

Define hocm murmur characteristics in details, Define HOCM Murmur character...

Define HOCM Murmur characteristics in details? Characteristics: The murmur is harsh, crescendo-decrescendo audible along the left sternal border, radiates to the base of heart

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd