Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Propose an experiment to test, Can enhancers work in Trans? That is, can an...

Can enhancers work in Trans? That is, can an enhancer on one piece of DNA activate a promoter on another piece of DNA? Propose an experiment to test this. Be sure to discuss any ap

Male reproductive disorders-absence of vesicular glands, Absence of vesicul...

Absence of vesicular glands In some bulls the vesicular glands are either absent or hypoplastic also sometimes accompanied by poorly developed ampullae. A characteristic sympt

How delayed complementary feeding cause pem, How Delayed Complementary Feed...

How Delayed Complementary Feeding Cause PEM? The mothers from poorer socioeconomic groups where PEM is more prevalent, delayed introduction of complementary foods (foods in add

Define dietary and non dietary factors - causation of cancer, Define Dietar...

Define Dietary and Non Dietary Factors - Causation of Cancer? Several dietary and non-dietary factors (including genetics) can increase the risk in the causation of cancer. Som

What is parasitism, Q. What is parasitism? The Parasitism is the ecolog...

Q. What is parasitism? The Parasitism is the ecological interaction in which a being lives at the expense of another. The parasite often doesn't cause immediate death of the ho

Explain water holding or hydration capacity and viscosity, Explain Water Ho...

Explain Water Holding or Hydration Capacity (WHC) and Viscosity? WHC refers to the 'ability of fibre to bind water', just as dry sponge does when soaked in water. WHC of the fi

Are mollusc metameric beings, Are mollusc metameric beings? Exclusively ana...

Are mollusc metameric beings? Exclusively analyzing this feature could it be said that molluscs are evolutionarily proximal to nematodes or to annelids? In molluscs there is no

Limerick, how do we write a limerick spell?

how do we write a limerick spell?

Explain femoral approach, Q. Explain Femoral Approach? This approach in...

Q. Explain Femoral Approach? This approach involves the insertion of a catheter over a guidewire i.e. inserted into a sheath in the right femoral artery. Systemic anticoagulati

Give the introduction to cardiac rehabilitation, Give the introduction to C...

Give the introduction to Cardiac rehabilitation? Cardiac rehabilitation services are comprehensive, long-term programs involving medical evaluation, prescribed exercise, cardia

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd