Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

Phylum porifera, PHYLUM  PORIFERA Definition and Introduction Low...

PHYLUM  PORIFERA Definition and Introduction Lowest  multicellular animals or metazoans without  true  tissues, i.e. , at  Cellular level or body organization. Familiar

Plants of the open water zone, Plants of the open water zone In this z...

Plants of the open water zone In this zone plants are restricted to the limnetic one and generally consist of phytoplankton such as dinoflagellates, blue green algae and green

Explain the birth in human biology, Explain the Birth in human biology? ...

Explain the Birth in human biology? In humans, birth of the infant occurs about 270 days after conception. The period during which the uterus contracts to expel the newborn

Define interferons - humoral mechanisms, Define Interferons - Humoral Mecha...

Define Interferons - Humoral Mechanisms Interferons are soluble proteins secreted naturally when cells become infected by foreign bodies. Infected lymphocytes release interfero

Explain the anaesthesia and analgesia, Explain the Anaesthesia and Analgesi...

Explain the Anaesthesia and Analgesia Most implant surgery can be carried out under local anaesthesia, although some patients will require sedation or general anaesthesia. The

Why ph regulation is important for living beings, Q. Why pH regulation is i...

Q. Why pH regulation is important for living beings? How mineral salts participate in this regulation? The prospective of hydrogen (pH) is a measure of the amount of hydrogen i

State cryptobiosis and explain the function of it, State Cryptobiosis and e...

State Cryptobiosis and explain the function of it. A dormant, or suspended, state of animation which allows some animals to survive severe conditions like extremely low tempera

Define microscopy and physiological analysis, Dr. Herbert discovers a cell ...

Dr. Herbert discovers a cell and he is convinced it is a plant cell. However, as a student of his genetics class, you do not agree with him. You do not believe in microscopy and ph

Define changing trends in dietary intake, Define Changing Trends in Dietary...

Define Changing Trends in Dietary Intake? As a practicing dietician, you must be sensitive to the society as a whole. The fat requirements have been worked out with a premise o

Vacuoles, VACUOLES  Some animals cells may have  one to a few small  fl...

VACUOLES  Some animals cells may have  one to a few small  fluid  filled vacuoles.. Plants  cells  in general  possess one or a few  large vacuoles. Vacuoles  of animals  cells

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd