Explain Itraconazole

It has a broader spectrum of activity than fluconazole. It is active against a wide variety of fungi including Cryptococcus neoformans, Aspergillus spp., Blastomyces dermatitidis, Coccidioides immitis,  Histoplasma capsulatum,  Paracoccidioides brasiliensis,  Pseudallescheria boydii,  Sporothrix spp., and dermatophytes. It also has good activity against most Candida spp. containing some strains of fluconazole-resistant C. glabrata. Itraconazole has no clinically meaningful activity against Fusarium  spp. or Zygomycetes. Itraconazole  is not recommended for treatment of meningitis because it does not cross the blood-brain barrier.