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Explain Itraconazole
It has a broader spectrum of activity than fluconazole. It is active against a wide variety of fungi including Cryptococcus neoformans, Aspergillus spp., Blastomyces dermatitidis, Coccidioides immitis, Histoplasma capsulatum, Paracoccidioides brasiliensis, Pseudallescheria boydii, Sporothrix spp., and dermatophytes. It also has good activity against most Candida spp. containing some strains of fluconazole-resistant C. glabrata. Itraconazole has no clinically meaningful activity against Fusarium spp. or Zygomycetes. Itraconazole is not recommended for treatment of meningitis because it does not cross the blood-brain barrier.
Monomeric enzymes Monomeric enzymes are those which consist of only a single polypeptide chain, so they cannot be dissociated into smaller units. Very few monomeric enzymes are
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When the level of AMP is high, this shows the requirement for more ATP synthesis. AMP stimulates PFK increases the rate of glycolysis and inhibits fructose 1 and 6- bisphosphatase
The holoenzyme is denatured by heat at very high temperature. It is found that two polypeptides, although denatured, contains chains that remain together as a unit, while two other
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