Explain Gene Expression - Nutrient Gene Interactions?

The last two decades have witnessed tremendous development in our understanding of the cellular processes at the molecular level including the mechanism of action of certain nutrients. This has been feasible largely by the application of modern molecule and cellular biological techniques within the discipline of nutrition. DNA (deoxyribonucleic acid) in all cells of a species, we already know, carries all of the genes for all the body's characteristics. However, not all genes are expressed in all cells at all times. Controls of gene expression exist, that determine which genes are transcribed and translated into gene products. Besides metabolic control mechanisms, which involve hormones, metabolites, ions, second messenger systems and others modify the phenotypic expression of genes.

Dietary factors, which include both nutritive and non-nutritive components, can influence gene expression at various levels. Specific nutrients can turn on or turn off specific genes. Nutrient-gene interactions have the potential to influence the life process from conception through growth and development to adulthood. These interactions are also likely to determine healthy life span by influencing both infectious and chronic degenerative diseases.

Although the Human Genome Project has unravelled the genetic code, gene expression is a process that is still under investigation. An understanding of the molecular mechanisms underlying human health and disease is fundamental to both prevention and treatment of disease. Ultimately, as knowledge about genetic identity expands and gene-nutrient interactions are well understood, nutritionists may be able to recommend nutrient intakes that enhance the expression of genes associated with good health and suppress the expression ,of genes associated with disease.