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Galactose Metabolism
Galactose goes to the liver via portal blood and is phosphorylated by galactokinase togalactose- 1 -phosphate (GIP) using ATP as a phosphate donor as shown in Figure. 1 -phosphate reacts with uridine diphosphate glucose to fom uridine diphosphategalactose catalyzed by galactose-I-phosphate uridyl transferuse. It is then convertedto UDP-glucose catalyzed by UDP-galactose 4-epimerase. Since this would be thewell-fed state, the glucose would be incorporated into the glycogen chain through theaction of glycogen synthase.
What is the futile cycle The futile cycle is avoided because covalent modification, by phosphorylation, has opposite effects on the enzymes concerned with the synthesis a
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