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Explain Delavirdine
Delavirdine (DLV, Rescriptor) - Delavirdine is the least potent NNRTI. A study comparing delavirdine/zidovudine/didanosine, delavirdine plus either zidovudine or didanosine, and zidovudine/didanosine in patients with mean CD4 cell counts of 295 cells/mm3 and <6 months prior HIV treatment showed only modest benefit from the triple combination. Unlike other NNRTIs, delavirdine enhances serum concentrations of protease inhibitors.
Among neonates, IE typically involves the tricuspid valve of structurally normal hearts and is associated with very high mortality rates. It is likely that many of these episodes
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