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Under the limiting oxygen conditions experienced in by vigorous exercise, the configuration of NADH by glycolysis exceeds the ability of the respiratory chain to oxidize it back to NAD+. The pyruvate produced by glycolysis in muscle is then converted to lactate by lactate dehydrogenase, a reaction which regenerates NAD+ and so allows glycolysis to continue to produce ATP. Furthermore, lactate is a metabolic dead-end in which it cannot be metabolized further until it is converted back to pyruvate. The Lactate diffuses out of the muscle and is carried in the bloodstream to the liver. Here it spread into liver cells and is converted back to pyruvate by lactate dehydrogenase. The pyruvate is then transformed to glucose by gluconeogenesis and the glucose is released back into the bloodstream ready to be taken up by skeletal muscle and brain. This cycle of reactions shown in the figure is known as the Cori cycle.
Explain Atazanavir Atazanavir (ATV, Reyataz) - Atazanavir (Medical Letter 2003; 45:89) is the first single-agent protease inhibitor with once-daily dosing. In clinical trials
Cholesterol, from stereos (solid) and the Greek chole- (bile) followed by the chemical suffix -ol for an alcohol is an organic chemical substance classified as a waxy steroid of fa
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Electrophoresis is the technique of separating the large molecules (for instance DNA fragments or proteins) from the mixture of identical molecules. An electric current is passed
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1- Describe the function of enzymes in catalyzing biological reactions ? 2-Descride enzymes ' role in reducign activation energy?
Q. Evaluate the Magnitude of ST Depression? It is intuitive that the magnitude of ST depression should correlate with the degree of the ischaemia. In patients with left main or
Coxal Glands There is a pair of coxal glands, in almost all the segments in Onychophora (Peripatus). Developmentally; in every segment a hollow follicle or somite arises and i
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