Explain Class adverse effects of Protease inhibitors 

Many protease inhibitors can cause gastrointestinal distress, increased bleeding in hemophiliacs, hyperglycemia, insulin resistance and hyperlipidemia and have been associated with increased risk of coronary artery disease. They have also been associated with a syndrome of lipodystrophy including fat wasting, reaccumulation and redistribution. All, especially higher doses of ritonavir, can cause hepatotoxicity, which may occasionally be severe and is more common in patients who are co-infected with HBV or HCV.