Explain causes of Fever - Immune System

We have seen that due to injury, cut or bite, the inflammatory response develop and this is localized or systemic. The localized response is confined to the site of injury only. The systemic response affects the body in case of a severe infection or a serious injury. In this case, the WBC count increases. Body temperature rises causing fever. This may be brought about by toxins produced by pathogens and by a protein called endogenous pyrogen. When enough pyrogen reaches the brain, the body's thermostat is reset to higher temperature allowing the entire body temperature to rise.