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Explain biomaterial implantation
When a biomaterial is introduced into the host, in addition to a host response there is also a material response. Immediately on implantation, there is an adsorption of proteins. These proteins come from the blood and tissue fluids at the wound site and later from cellular activity in the interfacial region. Once on the surface, the proteins (undenatured or denatured, intact or fragmented) can desorb or remain to mediate tissue implant interactions.
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With the development of electron microscopy, it was possible to have an in depth knowledge of the interface between the implant and the tissues. Branemark was the pioneer in the fi
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