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Anaplerotic Reactions
Anaplerotic reactions are reactions that replenish the intermediates of citric acid cycle. The special enzymatic mechanisms by which the pool of citric acid cycle intermediates can be replenished are called anaplerotic (filling-up) reactions. Anaplerotic reactions can increase the concentration of citric acid cycle intermediates, allowing an increased rate of oxidation of two-carbon units. As more intermediates are available, more moles of acetyl CoA can be processed.
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Synthesis of citratefrom acetyl CoA and oxaloacetate: Citrate synthase catalyses this aldol condensation reaction with the release of CoA. There are certain inhibitors to this re
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