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Adefovir dipivoxil (Hepsera)
This phosphonate nucleoside analog, administered as the oral prodrug, inhibits replication of HBV, including variants resistant to lamivudine. Adefovir treatment of HBeAg-positive or -negative chronic hepatitis B is associated with marked reductions in HBV DNA levels, aminotransferase normalization in 48% to 72% of patients, and histologic improvements in 53% to 64% at 48 weeks. More prolonged therapy results in higher rates of response; anti-HBeAg seroconversion occurs in 23% by 72 weeks. The antiviral effects of adefovir are similar in lamivudine-susceptible and -resistant HBV infections (MG Peters et al, Gastroenterology 2004; 126:91). Some experts recommend adefovir over lamivudine for long-term treatment of HBeAg-negative or cirrhotic patients because of the high risk of emergence of lamivudine resistance.
Depleted (Vulnerable) Species These are the species whose numbers are greatly reduced from those of the recent past, and they are continuing to decrease. It is the continued d
state 5 notification and feeding habits in some animals
Problem 1: Show the aims and applications of Epidemiology. Definition of Epidemiology. List aims of Epidemiology List applicationsof Epidemiology Problem 2
B o vi n e spongiform encephalopathy (BSE) Bovine spongiform encephalopathy (BSE) is a transmissible, neurodegenerative, fatal brain disease of cattle characterized by post
what is the excretory organ of lizard
Define Calamity and Emergency Management - nutritional needs of humans? During past many years, we have seen, as well as, realized -that natural calamities strikes countries, b
Conventional agro-industrial oilseed cakes Groundnut meal: It is readily available protein source byproduct from the extraction of groundnut, which is a popular human food i
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A simple method used to identify areas of high conservation priority is the selection of countries according to highest species richness. Among the top 12 countries identified this
Ophthalmic Data are limited on the effectiveness of antimicrobial prophylaxis for ophthalmic surgery, but postoperative endophthalmitis can be devastating. Most ophthalmologist
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