Explain about the chromium metabolism, Biology

Assignment Help:

Explain about the Chromium Metabolism?

Chromium appears to be absorbed throughout the small intestine, with absorption being higher in jejunum. The mechanism of absorption has not been well defined but appears to involve processes other than simple diffusion. At normal dietary intakes (10-40 mcg/day), the absorption ranges from 0.4 to 3.0% with absorption being higher at lower intakes. As you have studied for other minerals, even in the case of chromium, an inverse relation between intake and absorption appears to be a basal control mechanism to maintain the body levels of chromium. As compared to healthy individuals, insulin-dependent diabetic patients absorb 2-4 times more chromium. It appears that these patients have an impaired ability to convert inorganic form to usable form and therefore require higher chromium. Like other trace minerals, absorption of chromium is also influenced by some factors. Enhancers and inhibitors are listed in the Table.

Table: Factors influencing absorption

1300_Explain about the Chromium Metabolism.png

After absorption, chromium binds to plasma proteins for transportation. Both transferrin and albumin are capable of binding absorbed Cr. It has been suggested that transferrin is the main binder of newly absorbed chromium and albumin assumes the role of chromium acceptor and transporter if transferrin binding sites are unavailable. You have studied that transferrin has two metal binding sites, one is primarily for iron and the second is involved in chromium transport. During conditions of iron excess or iron overload such as iron storage diseases, all the metal transport sites on transferrin are occupied by iron. This may explain the high incidence of diabetes in haemochromatosis patients, which may be induced by chromium deficiency. Although transferrin and albumin play the major roles in transportation, other plasma proteins such as α and β globulins and lipoproteins are also involved. As you will go through the next section on 'Functions', you will realize that only organically complexed chromium i.e. GTF is active. It appears that absorbed inorganic chromium is transported to the liver, which is postulated to be the possible site for synthesis of metabolically active molecule. This molecule is held in a body pool and released as needed. Most ingested chromium is excreted in faeces. Inorganic chromium is excreted primarily by the kidney, with small amounts being excreted through hair, sweat and bile. Organically bound chromium is excreted through bile. The biologically active form of chromium performs several functions; the important ones are being subsequently discussed.


Related Discussions:- Explain about the chromium metabolism

Role of hormones in aging, Role of Hormones in Aging Aging as well ref...

Role of Hormones in Aging Aging as well reflects the inefficiency of the endocrine system. A change in the hormonal secretions may contribute to the development of physical ai

Tpes of diarrhoea, Tpes of Diarrhoea: Diarrhoea can be acute, chronicl...

Tpes of Diarrhoea: Diarrhoea can be acute, chroniclpersistent diarrhoea and dysentery.  If an episode of diarrhoea lasts less than 14 days, it is acute diarrhoea. Acute wat

Explain carbohydrates - nutritions, Explain Carbohydrates - Nutritions? ...

Explain Carbohydrates - Nutritions? Liberal amounts of carbohydrates should be given i.e. around 60% to 65% of the total energy. However, care must be taken regarding the maxim

Define the basic concepts behind the spectral techniques, Define the Basic ...

Define the Basic Concepts behind the Spectral Techniques? Energy is transmitted via electromagnetic waves that are characterized by their frequency and wavelength. The physical

Role of protein in metabolism, ROL E OF PROTEIN - Main organic comp...

ROL E OF PROTEIN - Main organic component of body. Unit is amino acid. Polymer of amino acids. Amino acids combine to each other by peptide bond. Formation of bone, t

Determine the ideal clinical conditions of teeth, The ideal clinical condit...

The ideal clinical conditions of teeth which we know already include: - the absence of pain. - less than 0.1 mm initial hori-ontal mobility under lateral forces of less than

Relation between the hypophysis and the hypothalamus, Q. What is the relati...

Q. What is the relation between the hypophysis and the hypothalamus? The hypothalamus is a part of the brain situated just above the hypophysis and the hypothalamus gets centra

Compare the time-course to the rising phase, Assume you are injecting a sub...

Assume you are injecting a sub threshold depolarizing current step into a neuron. Draw the corresponding membrane voltage response; be sure to indicate the shape of the voltage cha

Maintenance in the continuing care cycle, Maintenance in the Continuing Car...

Maintenance in the Continuing Care Cycle Impaired dexterity: Any impairment of dexterity, even if it is temporary, may be detrimental to dental implants because home maintena

Conditions do most seeds need in order to begin germination, a) What condit...

a) What conditions do most seeds need in order to begin germination?  b) What other condition do the seedlings need to continue growth to mature plants?   a) Most seed

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd