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Explain about Bioactive materials
Bioactive materials: Certain glasses, ceramics, and glass-ceramics that contain oxides of silicon, sodium, calcium and phosphorus (SiO2 , Na2O, CaO, and P2O5 ) form a chemical bond with bone, resulting in a strong mechanical implant bone bond. These materials do bond to bone through a time-dependent, kinetic modification of the surface triggered by their implantation within living bone. An ion-exchange reaction between the bioactive implant and surrounding body fluids results in the formation of a biologically active calcium phosphate layer on the implant. This layer is chemically and crystallographically equivalent to the mineral phase in bone which is responsible for the strong interfacial bonding.
Empiric Initial Therapy Until susceptibility results are available, empiric initial treatment consists of a 4-drug regimen of isoniazid, rifampin, pyrazinamide and ethambutol.
Hydrolytic driving force. The hydrolysis of pyrophosphate to orthophosphate is important in driving forwards biosynthetic reactions such as the synthesis of DNA. THis hydrolytic re
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